Results RCAd-LTH-shPD-L1 cells secreted anti-VEGF antibodies and inhibited the expression of PD-L1 in cancer cells. Moreover, RCAd-LTH-shPD-L1 exerted a specific cytotoxic effect on human cancer cells, but not on murine cancer cells or normal human cells. RCAd-LTH-shPD-L1 elicited a more...
一种携带shSTAT3/shPD-L1重组质粒的减毒沙门氏菌载体及其应用本发明公开了一种携带shSTAT3/shPDL1重组质粒的减毒沙门氏菌载体及其应用,属于生物技术领域.本发明在同一个表达载体中采用两个启动子分别表达两个shRNA,成功构建携带shSTAT3/shPDL1重组质粒的减毒沙门氏菌载体;shSTAT3/shPDL1重组质粒能够同时沉默结...