A review and meta-analysis of the effects of N-methyl-D-aspartate (NMDA) receptor antagonists in treating major depression has confirmed that ketamine is the only such drug to date that has demonstrated antidepressant efficacy across multiple trials. Authors of the review stated, however, that ...
Ketamine acts as a rapid clinical antidepressant at 25 min after injection with effects sustained for 7 days. As dissociative effects emerging acutely after injection are not entirely discernible from therapeutic action, we aimed to dissect the differences between short-term and long-term response ...
These findings indicate that ketamine is rapid, safe, and effective in the short term for acute care in hospitalized suicidal patients, they write. However, they stress that ketamine is a drug with a potential for abuse and say longer follow-up of larger samples will be necessary to examine ...
Sedation with ketamine and low-dose midazolam for short-term procedures requiring pharyngeal ... H Novak,PK Akeson,J Akeson - 《Pediatric Anesthesia》 被引量: 32发表: 2010年 Development of an optimal sampling schedule for children receiving ketamine for short-term procedural sedation and analgesia ...
Under ketamine (50 mg/kg) and xylazine (10 mg/kg) anaesthesia, periodontitis was induced by ligation of the bilateral mandibular first molar with 4-0 sterile silk suture (Bioline, Anápolis, GO, Brazil). Control animals underwent to sham operation. After the surgery, animals received analgesic...
Short-term effects of heroin in man. Is EEG related to behavior? Volavka J, Levine R, Feldstein S, Fink M. J, Volavka,R, Levine,S, Feldstein,... - 《Archives of General Psychiatry》 被引量: 20发表: 1974年 Naltrexone, an Antagonist for the Treatment of Heroin Dependence: Effects ...
In a rapidly changing environment, we often know when to do something before we have to do it. This preparation in the temporal domain is based on a ‘perception’ of elapsed time and short-term memory of previous stimulation in a similar context. These
Combining Ketamine and Propofol ("Ketofol") for Emergency Department Procedural Sedation and Analgesia: A Review (PSA) in that it is a "dissociative" anesthetic that functions by blocking communication between the thalamic and limbic regions of the brain, thereby ......
NMDAR inhibition-independent antidepressant actions of ketamine metabolites Major depressive disorder affects around 16 per cent of the world population at some point in their lives. Despite the availability of numerous monoaminergic-based antidepressants, most patients require several weeks, if not months...
934 were found differentially expressed in 5-MeO-DMT-treated cerebral organoids.In silicoanalysis reinforced previously reported anti-inflammatory actions of 5-MeO-DMT and revealed modulatory effects on proteins associated with long-term potentiation, the formation of dendritic spines, including those invo...