Blockade of NMDAR-dependent burst firing in the lateral habenula (LHb) has been proposed to mediate the rapid effects of ketamine, but the mechanisms underlying its sustained antidepressant effects are not understood.Here, Ma et al. map the anti-depressant time course of a single systemic ...
Finally, neuroplasticity may not only play a role in positive long-term effects of psychedelics, but also undesirable ones. Drug-induced neuroplastic changes in sensory regions could conceivably be a factor in psychedelic-induced flashbacks, as well as the rarer and more severe hallucinogen persisting...
including three studies on ketamine. We determined the Yeo network that contained each brain region that exhibited a significant correlation, and then we averaged across the correlations associated with each Yeo network, resulting in the mean correlation between each Yeo network...
We broadly describe human biological findings, as well as protective effects of medications such as lithium, clozapine, and ketamine associated with modifying risk of engaging in suicidal behavior that are readily translatable to animal models. Endophenotypes of suicidal behavior, studied in animal ...
Long-Term Potentiation and Depression. Intrinsic in- hibitory interneurons in the hippocampus may also con- trol long-term modifications of synaptic strength induced by synaptic transmission (Buzsaki et al. 1996; Maccaferri and McBain 1996; Miles et al. 1996; Tsubokawa and Ross 1996; McMahon and...
(dose-dependent effect) Alone Evoked activity: ↑ LFP amplitude, ↑ long lasting LFP (compared to awake) With Xylazine: Evoked activity: LIV onset; Spontaneous activity: LV onset; ↓ frequency, ↑ amplitude (dose-dependent effect) [49] [114] see Ketamine [115] Alone: Evoked activity: ↑ ...