MicrobiomeMicrobiotaMicrobiota-gut-brain axisShort-chain fatty acidsThe role of the intestinal microbiota as a regulator of gut-brain axis signalling has risen to prominence in recent years. Understanding the relationship between the gut microbiota, the metabolites it produces, and the brain will be ...
The short-chain fatty acids (SCFAs) butyrate, propionate and acetate are microbial metabolites and their availability in the gut and other organs is determined by environmental factors, such as diet and use of antibiotics, that shape the diversity and me
Diet-induced metabolic changes of the human gut microbiome: importance of short-chain fatty acids, methylamines and indoles Background The human intestine contains a complex and diverse symbiotic microbial system that is mainly composed of bacteria, fungi, viruses, archaea, and protozoans [1]. Micr...
A recent large genetic study by Sanna et al., published in Nature Genetics, has shown that short-chain fatty acids, which are produced by gut microbes, have a significant causal effect on insulin secretion, postprandial glycaemic responses and risk of type 2 diabetes.Cristina...
Here, using a drink-in-the-dark mouse model, we identified a microbiome metabolite-based novel treatment (sodium valerate) that can reduce excessive alcohol drinking. Sodium valerate is a sodium salt of valeric acid short-chain fatty acid with a similar structure as γ-aminobutyric acid (GABA)...
Short-chain fatty acids (SCFAs) are the main metabolites produced by bacterial fermentation of dietary fibre in the gastrointestinal tract. The absorption of SCFAs is mediated by substrate transporters, such as monocarboxylate transporter 1 and sodium-coupled monocarboxylate transporter 1, which promote ...
Short-chain fatty acids (SCFAs) are carboxylic acids with carbon atom numbers less than 6, which are important metabolites of gut microbiome. Existing research shows that SCFAs play a vital role in the health and disease of the host. First, SCFAs are the key energy source for colon and ...
Short-chain fatty acid delivery: assessing exogenous administration of the microbiome metabolite acetate in mice. Physiol Rep. 2019. https://doi.org/10.14814/PHY2.14005. Article Google Scholar Gill PA, van Zelm MC, Muir JG, Gibson PR. Review article: short chain fatty acids as potential ...
of the gut microbiota and short-chain fatty acids in modulating metabolic responses to diet. Nevertheless, the findings so far seem to support current dietary guidelines encouraging the intake of fibre rich plant–based foods and discouraging the intake of animal foods rich in saturated fatty acids...
At baseline, 2.1% of microbiome was comprised of bifidobacteria. After 3 weeks, bifidobacteria was increased to 5.8% by RS II and11.1% by RS IV. A 5x increase is nothing to scoff at in a triple crossover study. Short-chain fatty acids: Resistant Starch ...