sgn-b7h4v结构式是由一个全人源化IgG1的单抗偶联MMAE,并通过组织蛋白酶linker连接的ADC。SGN-B7H4V被设计为与肿瘤细胞表面的B7-H4/ADC复合物结合并将其内化,并释放载荷MMAE,诱导MMAE介导。©2022 Baidu |由 百度智能云 提供计算服务 | 使用百度前必读 | 文库协议 | 网站地图 | 百度营销 ...
SGN-B7H4V is designed to bind and internalize the B7-H4/ADC complex from the surface of malignant cells and release the cytotoxic payload MMAE. The antitumor activity of SGN-B7H4V may be multimodal as SGN-B7H4V can induce tumor cell death through several mechanisms, including MMAE-mediated ...
Background SGN-B7H4V is an investigational vedotin antibody-drug conjugate (ADC) directed to B7-H4, an immune checkpoint ligand with elevated expression on multiple solid tumor types, including breast, ovarian, and endometrial tumors.1 SGN-B7H4V is composed of an anti-B7-H4 human monoclonal ...