sgn-b7h4v结构式sgn-b7h4v结构式是由一个全人源化IgG1的单抗偶联MMAE,并通过组织蛋白酶linker连接的ADC。SGN-B7H4V被设计为与肿瘤细胞表面的B7-H4/ADC复合物结合并将其内化,并释放载荷MMAE,诱导MMAE介导。©2022 Baidu |由 百度智能云 提供计算服务 | 使用百度前必读 | 文库协议 | 网站地图 | 百度营销 ...
SGN-B7H4V is a novel, investigational vedotin antibody–drug conjugate directed to B7-H4 with proposed mechanisms of action including monomethyl auristatin E (MMAE)-directed cytotoxicity, bystander effect, antibody-dependent cellular cytotoxicity, and antibody-dependent cellular phagocytosis. SGN-B7H4V ...
RESEARCH GRADE SGN-B7H4V 单克隆抗体 CBNumber: CB412783441 分子式: 分子量: 0 MOL File: Mol file 化学性质安全信息用途供应商1 RESEARCH GRADE SGN-B7H4V 单克隆抗体化学性质 安全信息 RESEARCH GRADE SGN-B7H4V 单克隆抗体性质、用途与生产工艺
Product Name:Research Grade SGN-B7H4V (DHJ14805) Synonyms:Research Grade SGN-B7H4V (DHJ14805) CAS: MF: MW:0 EINECS: Mol File:Mol File Information Error Report Your Email: Browse by NationalityResearch Grade SGN-B7H4V (DHJ14805)SuppliersChina suppliers ...
We also evaluate the contribution of SGN-B7H4V-induced immune activation to antitumor activity in combination with an anti-PD1 agent in an immunocompetent mouse model. In vitro, tumor cells treated with SGN-B7H4V showed several hallmarks of immunogenic cell death, including calreticulin exposure ...
Background SGN-B7H4V is an investigational vedotin antibody-drug conjugate (ADC) directed to B7-H4, an immune checkpoint ligand with elevated expression on multiple solid tumor types, including breast, ovarian, and endometrial tumors.1 SGN-B7H4V is composed of an anti-B7-H4 human monoclonal ...