sgn-b7h4v结构式是由一个全人源化IgG1的单抗偶联MMAE,并通过组织蛋白酶linker连接的ADC。SGN-B7H4V被设计为与肿瘤细胞表面的B7-H4/ADC复合物结合并将其内化,并释放载荷MMAE,诱导MMAE介导。©2022 Baidu |由 百度智能云 提供计算服务 | 使用百度前必读 | 文库协议 | 网站地图 | 百度营销 ...
Methods: SGNB7H4V-001 (NCT05194072) is a phase 1, first-in-human, multicenter, open-label trial evaluating the safety, tolerability, pharmacokinetics (PK), and antitumor activity of SGN-B7H4V in pts with advanced solid tumors. This study includes 3 parts: dose escalation (Part A), dose ...
RESEARCH GRADE SGN-B7H4V 单克隆抗体 CBNumber: CB412783441 分子式: 分子量: 0 MOL File: Mol file 化学性质安全信息用途供应商1 RESEARCH GRADE SGN-B7H4V 单克隆抗体化学性质 安全信息 RESEARCH GRADE SGN-B7H4V 单克隆抗体性质、用途与生产工艺
Product Name:Research Grade SGN-B7H4V (DHJ14805) Synonyms:Research Grade SGN-B7H4V (DHJ14805) CAS: MF: MW:0 EINECS: Mol File:Mol File Information Error Report Your Email: Browse by NationalityResearch Grade SGN-B7H4V (DHJ14805)SuppliersChina suppliers ...
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余沁斋(李培森饰)为了保护自身只好帮助救王琴(徐熙颜饰),最终迫使严锟放人严锟则以不知情为借口拖延时间。郑力祥意外得知玉皇观情况异常,巩向光让武平前去侦察,得知那里军统秘密监狱。巩向光带武平、郑力祥二人趁夜潜入劫狱,军统用火力将其封锁监狱内并让边国烈派...
SGN-B7H4V is designed to bind and internalize the B7-H4/ADC complex from the surface of malignant cells and release the cytotoxic payload MMAE. The antitumor activity of SGN-B7H4V may be multimodal as SGN-B7H4V can induce tumor cell death through several mechanisms, including MMAE-mediated ...
Background SGN-B7H4V is an investigational vedotin antibody-drug conjugate (ADC) directed to B7-H4, an immune checkpoint ligand with elevated expression on multiple solid tumor types, including breast, ovarian, and endometrial tumors.1 SGN-B7H4V is composed of an anti-B7-H4 human monoclonal ...