图3SGLT2i与GLP1RA联合应用的多效性和治疗效果 来源:Terenzi DC, Bakbak E, Teoh H, et al. Restoration of blood vessel regeneration in the era of combination SGLT2i and GLP-1RA therapy for diabetes and obesity. Cardiovasc Res. 2024 ...
临床试验也发现,SGLT2i给药30天后,与使用磺酰脲类药物的患者相比,IL-1β与TNF-α水平显著降低。 同样,GLP-1RA也被证实有抗炎作用,比如有助于将人单核细胞从促炎M1样表型转变为抗炎M2样表型,减少IL-6、IL-1β等的释放,增加IL-4、IL-10、TGF-β1等抗炎因子水平。 这种炎症水平的降低有助于保护2型糖尿病...
研究发现,相较于单药治疗,SGLT2i和GLP-1RA联合治疗似乎能更进一步降低2型糖尿病患者心血管和肾脏不良事件的风险。 这提示我们SGLT2i和GLP-1RA的心肾保护机制可能不尽相同,联合治疗或许可以达到不同心肾保护机制的互补,从而强化心肾保护效应,为合并心肾并发症或存在高危因素的2型糖尿病患者的治疗提供了新的思路。...
研究发现,相较于单药治疗,SGLT2i和GLP-1RA联合治疗似乎能更进一步降低2型糖尿病患者心血管和肾脏不良事件的风险。 这提示我们SGLT2i和GLP-1RA的心肾保护机制可能不尽相同,联合治疗或许可以达到不同心肾保护机制的互补,从而强化心肾...
图3SGLT2i与GLP1RA联合应用的多效性和治疗效果 来源:Terenzi DC, Bakbak E, Teoh H, et al. Restoration of blood vessel regeneration in the era of combination SGLT2i and GLP-1RA therapy for diabetes and obesity. Cardiovasc Res. 2024 Feb 17;119(18):2858-2874. ...
图3SGLT2i与GLP1RA联合应用的多效性和治疗效果 来源:Terenzi DC, Bakbak E, Teoh H, et al. Restoration of blood vessel regeneration in the era of combination SGLT2i and GLP-1RA therapy for diabetes and obesity. Cardiovasc Res. 2024 Feb 17;119(18):2858-2874. ...
Estimated Lifetime Cardiovascular, Kidney, and Mortality Benefits of Combination Treatment With SGLT2 Inhibitors, GLP-1 Receptor Agonists, and Nonsteroidal MRA Compared With Conventional Care in Patients With Type 2 Diabetes and Albuminuria https://pubmed.ncbi.nlm.nih.gov/37952217/...
SGLT-2抑制剂和GLP-1受体激动剂的联合使用_替代终点和硬终点的潜在好处.pdf,1879 Send Orders for Reprints to reprints@benthamscience.ae Current Pharmaceutical Design, 2018, 24, 1879-1886 REVIEW ARTICLE Combination of SGLT-2 Inhibitors and GLP-1 Receptor Agoni
SGLT-2i和GLP-1RA联合使用降低2型糖尿病合并急性心肌梗死患者心血管事件发生率 近些年来,钠-葡萄糖协同转运蛋白-2抑制剂(glucose sodium-cotransporter-2 inhibitors,SGLT-2i)与胰高血糖素样肽-1受体激动剂(glucagon-like peptide-1 receptor agonists,GLP-1RA)在降糖之外的获益备受关注。2024年1月,发表在Cardiovasc...
Combination treatment of SGLT2 inhibitors and GLP-1 receptor agonists: symbiotic effects on metabolism and cardiore- nal risk. Diabetes Ther. 2018;9:919-26.Goncalves E, Bell DSH. Combination Treatment of SGLT2 Inhibitors and GLP-1 Receptor Agonists: Symbiotic Effects on Metabolism and Cardiorenal...