SGLT-2抑制剂和GLP-1受体激动剂在绝对量表上对心力衰竭、慢性肾病或使用盐皮质激素受体拮抗剂的患者的益处最大。与DPP-4抑制剂相比,SGLT-2抑制剂(卡格列净、达格列净、恩格列净)和GLP-1受体激动剂(杜拉糖肽、艾塞那肽、利拉鲁...
SGLT-2抑制剂和GLP-1受体激动剂在绝对量表上对心力衰竭、慢性肾病或使用盐皮质激素受体拮抗剂的患者的益处最大。与DPP-4抑制剂相比,SGLT-2抑制剂(卡格列净、达格列净、恩格列净)和GLP-1受体激动剂(杜拉糖肽、艾塞那肽、利拉鲁肽、司美格鲁肽)类别中的单个药物的高钾血症发生率始终较低[28]。 在这项队列...
SGLT-2抑制剂和GLP-1受体激动剂的联合使用_替代终点和硬终点的潜在好处.pdf,1879 Send Orders for Reprints to reprints@benthamscience.ae Current Pharmaceutical Design, 2018, 24, 1879-1886 REVIEW ARTICLE Combination of SGLT-2 Inhibitors and GLP-1 Receptor Agoni
Many questions remain unanswered, however, regarding the therapeutic effects of GLP-1 agonists and SGLT2 inhibitors in HF. Here's an overview of what we've learned so far about the potentially beneficial role of these therapies in treating patients with HF. Cardioprotective Benefits of Newer Anti...
在2013~2015年接受SGLT2i治疗的T2DM患者的一个大型联合美国商业索赔数据库中,来自>19 000名患者的中位随访6.5个月的严重尿路感染发生率约为1.9%[31]。在倾向评分匹配分析中,与接受二肽基肽酶-4(DPP-4)抑制剂或胰高血糖素样肽-1受体(GLP-1)激动剂的患者...
Heart Failure (HF) in the SGLT2 Inhibitor (SGLT2i) and GLP1 Receptor Agonist (GLP1-RA) Era: Does Hypertension (HTN) Matter?doi:10.1681/ASN.20233411S1864cSydney E. HartsellSalt Lake City Health Care System, Salt Lake City, UT;Amara Sarwal...
此前,资本市场对于SGLT2抑制剂较为看好,高涨的研发热情推动其度过平台期(2017年)。 在热门靶点GLP-1与SGLT2的推动下,相对成熟的降糖药市场,其规模增速罕见地突破10%。2022年,全球糖尿病药物的市场规模达到近600亿美元,SGLT2抑制剂贡献的市场份额逼近胰岛素(21% VS 26%,对于部分药物的心衰等适应症未做出完全区分...
that was shown to significantly reduce atherothrombotic events compared with placebo in diabetic HF patients, suggesting that dual SGLT1/2 inhibitor may have additional properties vs. SGLT2-i. The hypothesis of this study is that dual SGLT1/2 inhibition by sotagliflozin improves thrombogenic profil...
SGLT2i lowers the risk of SCD only in heart failure patients. Graphical AbstractIntroduction Cardiac arrhythmias are associated with increased morbidity and mortality, especially in patients with Type 2 diabetes mellitus (T2DM), heart failure (HF) or chronic kidney disease (CKD) [1, 2]. Compared...
P-1RA治疗也可能改善不良心血管后果,超过单独使用任何一类药物所能达到的效果。17-19因为SGLT2i和GLP-1RA药物家族都表现出广泛的全身活动,了解每种类别如何影响血管稳态对于确定缓解CV事件的最佳治疗方案非常重要。 Using data from both ...