近年来,胰高血糖素样肽-1受体激动剂(GLP-1 RA)和钠-葡萄糖共转运蛋白2抑制剂(SGLT2i)在减少蛋白尿、延缓血清肌酐翻倍率和推迟ESKD进展方面显示出了效果【1】。 2024年11月6日,Ming-Hsien Tsai等研究学者在期刊Journal of ...
Introduction: Euglycemic diabetic ketoacidosis (DKA) is a known adverse effect associated with the use of SGLT2 inhibitors. The concomitant initiation of GLP1 agonists with SGLT2 inhibitors presents a potential synergistic risk, precipitating metabolic acidosis without significant hyperglycemia. The ...
17 Similar results were demonstrated in a meta-analysis of cardiovascular and kidney outcomes with GLP-1 receptor agonists alone and in combination with SGLT2 inhibitors: In people with type 2 diabetes, the benefits of GLP-1 receptor agonists are consistent regardless of SGLT2 inhibitor use.18 ...
upon these findings, we conducted this longitudinal investigation using an extensive global medical records database to explore the associations between GLP-1 RAs and mortality, adverse cardiovascular and kidney-related events in a substantial cohort of individuals with type 2 diabetes concomitant with ...
The use of nsMRAs is still emerging, and studies investigating their combination with SGLT2is and GLP-1RAs are scarce. In type 1 diabetes, combination therapies have primarily focused on glucose control and safety, with several randomized controlled trials investigating the effects of combining ...
Patients with Type 1 diabetes with concomitant GLP-1 agonists used for at least one year were included. Observed outcomes were the change in A1C, weight, and basal insulin use compared at baseline and 12 months using mixed models repeated measures. ...
Few studies explored the effect of the combination of glucose sodium-cotransporter-2 inhibitors (SGLT-2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) on the incidence of cardiovascular events in patients with type 2 diabetes (T2D) and acute myocardial infarction (AMI). Methods We re...
CV, cardiovascular; GLP-1RA, glucagon-like peptide-1 receptor agonist; HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction; MI, myocardial infarction; SGLT2i, sodium-glucose cotransporter 2 inhibitor....
In PIONEER 2, RYBELSUS®went head-to-head against the most prescribed SGLT-2i with mean change in A1C from baseline to 26 weeks as a primary endpoint and mean change in body weight from baseline to 26 weeks as a confirmatory secondary endpoint.1,3,4 ...
Mechanisms underlying long-term sustained weight loss and glycemic normalization after obesity surgery include changes in gut hormone levels, including glucagon-like peptide 1 (GLP-1) and peptide YY (PYY). We demonstrate that two peptide biased agonists