demonstrated dual effects on gene expression in PC3 cells. It mediated feedback upregulation of genes related to autophagy, organelle acidification V-ATPase (ATP6V-0E1, −1D, −1E1, −1G1, −1H), and genes encoding subunits of mitochondria respiratory chain enzymes [complex-I: (ND1, ...
Demographic, clinical, biochemical and medication data were collected from medical charts and our local digital database:EVOLVE and CVWeb. Patients had to meet the DAPA-HF inclusion criteria to be deemed eligible for dapagliflozin therapy. Results Table 1 summarises the baseline clinical data and ...
In spite of its sufficient inhibitory effects against SGLTs, phlorizin was ultimately considered to be inappropriate for further development as an antihyperglycemic medication due to some critical drawbacks. First, as described above, phlorizin inhibits both SGLT1 and SGLT2 with low therapeutic ...
Since SGLT2 inhibitors lower plasma glucose level independently of insulin, they can also be used for patients with T1DM as concomitant medication with insulin [52]. Table 4. Patients considered for SGLT2 inhibitor treatment in the past, the present, and the future. Table 5 summarizes the ...