Nevertheless, some undesirable adverse effects caused by the administration of these medications, including hypoglycemia, gastrointestinal symptoms, weight gain, and hepato-renal toxicity, have increased demand for the discovery of safer antidiabetic agents with novel therapeutic mechanisms [3]. After the ...
Table 5 summarizes the points required for antidiabetic medications. SGLT2 inhibitors fulfil many of these points, indicating their great potential in the management of T2DM. Table 5. Potential of SGLT2 inhibitors in treatment of T2DM. Meta-analysis suggests that the cardiorenal benefits of SGLT2...
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combination therapy may be required because of the limited efficacy of single-target drugs; however, medications are becoming more costly, and there is also the risk of developing the combined side effects of each drug. Thus, identifying a multi-target drug may be the best strategy to improve ...