In people with T2D and established cardiovascular disease, the international guidelines for T2D recommend the use of GLP-1 RA or sodium glucose co-transporters 2 inhibitors (SGLT-2i) as first-line treatment (independent of HbA1c), based on multiple trials demonstrating their cardio-renal benefits...
unprecedented therapeutic benefits have clearly been observed for CKD as well. The relative risk reductions with SGLT2 inhibitors approach 40% for substantial decline in estimated glomerular filtration rate, KF, and death in populations with CKD
In recent years, a number of drugs have emerged that have significant cardio-renal protective effects in patients with diabetes, and a typical example is sodium-glucose cotransporter 2 inhibitor (SGLT2i), glucagon-like peptide-1 receptor agonist (GLP-1RA), and nonsteroidal mineralocorticoid ...
If a patient has a sulfa allergy the previous 2 options are not suit- able, but this one may be. Invokana works by inhibiting the sodium glucose cotransporter 2 (SGLT2), which causes a reduction in the reabsorption of filtered glucose. The drug also causes the patient to excrete excess gl...
People with diabetes and hyperglycaemia who are admitted with Covid-19 have longer lengths of stay and higher mortality compared to other Covid-19 patients (Hartmann-Boyceet al, 2020). Prescribing SGLT2 inhibitors and insulin infusion to hospitalised patient...
GLP-1 receptor agonists and SGLT-2is were found to exert striking benefits on the heart, liver, kidney, and even the brain [34,35,36,37,38,39,40]. Emerging research indicates that these benefits are conferred by pleiotropic mechanisms, that is, pathways distinct from those involved in glu...
SGLT2 inhibitors, which include canagliflozin, are considered a first-line therapy for diabetics at risk of kidney and heart disease. Some studies have shown that this class of drugs increases serum phosphate levels, which lowers the most active form of vitamin D (1,25-hydroxyvitamin D) in th...
Moreover, it was proven that the combination of these two medications is safe for patients and more effective than rosuvastatin therapy alone [123]. As we are concerned with the treatment of lipid disorders, it is worth mentioning pemafibrate’s efficiency in reducing liver stiffness. This ...
This could be potentially due to clinicians assuming that HFmrEF constitutes HFrEF with only partially recovered LVEF, or because patients are already treated with these medications for other medical conditions, e.g., hypertension or previous CAD [51]. 8. Future Perspectives There is a need for ...
9 RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook AcronymDefinition T2DMType 2 Diabetes Mellitus T2DMThe 2 Dimensional Metroids Copyright 1988-2018AcronymFinder.com, All rights reserved. Suggest new definition ...