Thrombocytopenia has rarely been reported in mixed connective tissue disease (MCTD). We observed two patients with MCTD and severe thrombocytopenia, necessitating splenectomy in one, while both patients were treated with corticosteroids. This is another, less favourable, feature of adult MCTD.doi:...
A study to evaluate the safety, tolerability and efficacy of MHV370 in participants with Sjogren’s Syndrome (SjS) or Mixed Connective Tissue Disease (MCTD):https://classic.clinicaltrials.gov/ct2/show/NCT04988087
Severe liver dysfunction due to bosentan in a patient with mixed connective tissue disease A 70-year-old Japanese woman was referred to our department due to a skin ulcer on her fifth left toe in July 2006. She had been diagnosed as having mixed ... Yayoi NAGAIEtsuko OKADASayaka MIHARAKen...
myasthenia gravis 9/0 493/4 502/4 7/0 462/3 469/3 2/0 31/1 33/1 Connective tissue diseases Systemic sclerosis Systemic lupus erythematosus Polymyositis– dermatomyositis Other connective tissue disease, including Sjogren's disease 29/1 9/0 17/1 0 2/0 367/1 257/0 78/1 16/0 16/0 ...
Although hepatomegaly is reported to occur occasionally in patients with mixed connective tissue disease (MCTD) or Sj枚gren's syndrome (SS), autoimmune liver diseases such as primary biliary cirrhosis, sclerosing cholangitis, and autoimm... JK Min,NI Han,JA Kim,... - 《Journal of Korean Med...
(heterozygote factor V Leiden gene mutation, prothrombin gene mutation, elevated anticardiolipin antibodies (> 15 g/L), or presence of lupus anticoagulant), autoimmune disease (systemic lupus erythematosus, mixed connective tissue disorder, or Type 1 diabetes) or advanced maternal age (≥ 40 years)...
HEK293T-hACE2 cells were seeded in 96-well tissue culture plates at a density of 1.75 × 104cells per well overnight. Three-fold serial dilutions of heat-inactivated serum samples were prepared and mixed with 50 µl of pseudovirus. The mixture was incubated at 37 °C for 1 h...
Frequency not reported: Disease progression, abnormal gait, intermittent pyrexia, nodule, sudden death, central line infection, clostridial infection, ear infection, Enterobacter sepsis, fungal infection, Klebsiella sepsis, localized infection, Pseudomonas infection, septic shock, transfusion reaction, overdose...
autoimmune memory, correlated with disease severity12. At the time of publication of our study, evidence of autoreactivity was mounting in severe disease, with observations of autoantibody-linked blood clotting6, anti-interferon antibodies7, connective-tissue-disease-associated interstitial lung disease8...
connective tissue. There are many types of EDS, and all of them involve joint hypermobility (double-jointedness), fragile tissue, and fragile/easily-bruised skin. Some types of EDS such asVascular Typecan cause arterial or organ rupture because the connective tissue of the organs and veins are...