Hence, we established a CRF-induced abnormal water transport model in rat colon, and evaluated the effects of 5-HT 3 receptor antagonists including ramosetron, alosetron, and cilansetron, and the antidiarrheal
Over the past 10 years, 5-HT3-receptors have been extensively investigated. Whilst it is generally accepted that 5-HT3-receptor antagonists attenuate emesis induced by a variety of stimuli, an extensive body of evidence indicates that these ligands may also alleviate some of the symptoms associate...
Serotonin (5-HT3) receptor antagonists are a class of antiemetic medications often used to prevent nausea and vomiting among patients undergoing chemotherapy, radiotherapy or surgery. However, recent studies suggest that these agents might be associated with increased cardiac harm. To examine this furth...
Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel. Science 254, 432–437 (1991). Article ADS CAS Google Scholar Machu, T. K. Therapeutics of 5-HT3 receptor antagonists: current uses and future directions. Pharmacol. Ther. 130, 338–347 (2011...
Nicotinic acetylcholine receptors and 5-HT3 serotonin receptors are present on presynaptic nerve terminals in the striatum, where they have been shown to be involved in the regulation of dopamine release. Here, we explored the possibility that both receptor systems function on the same individual ner...
5-HT receptor agonists and antagonists used for various assays, some have entered clinical trials, which would be new cancer therapies.
Antidepressants with a Rapid Onset of Action by Lucas G, Rymar VV, Du J, Mnie-Filali O, Bisgaard C, Manta S, Lambas-Senas L, Wiborg O, Haddjeri N, Piñeyro G, Sadikot AF, Debonnel G. Université McGill, Département de Psychiatrie, ...
Greenshaw, Andrew J and Silverstone, Peter H., “The Non-Antiemetic Uses of Serotonin 5-HT3 Receptor Antagonists”, Drugs, 1997, 20-39, vol. 53(1), Adis International Limited. Bufton, Kate E.; Steward, Lucinda J.; Barber, Peter C.; and Barnes, Nicholas M., “Distribution and Char...
DNA encoding human 5-HT3-C has been cloned and characterized. The recombinant protein is capable of forming biologically active human 5-HT3-C protein. The cDNA has been expressed in recombinant host cells that produce active recombinant protein. In addition, the recombinant host cells are utilize...
This hypothesis is supported by treating vomiting in children with acute gastroenteritis with 5-HT3 receptor antagonists.EBSCO_AspPLoS Pathogens