Serotonin receptor 4 (5-HT4R) plays an important role in regulating mood, anxiety, and cognition, and drugs that activate this receptor have fast-acting antidepressant (AD)-like effects in preclinical models. However, 5-HT4R is widely expressed throughout the central nervous system (CNS) and...
Antidepressants with a Rapid Onset of Action by Lucas G, Rymar VV, Du J, Mnie-Filali O, Bisgaard C, Manta S, Lambas-Senas L, Wiborg O, Haddjeri N, Piñeyro G, Sadikot AF, Debonnel G. Université McGill, Département de Psychiatrie, Bâtiment de Recherche et de Formation, Bureau ...
Lefebvre H, Dhib M, Godin M, Contesse V, Delarue C, Rieu M, Wolf LM, Vaudry H, Kuhn JM. Effect of the serotonin 5-HT4 receptor agonist cisapride on aldosterone secretion in corticotropic insufficiency and primary hyperaldosteronism. Neuroendocrinology ,1997, 66, pp. 229-233....
This invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof with 5-HT4 agonistic activities, which is useful in the t... O Hiroyuki,F Akiyoshi,T Yukinori 被引量: 0发表: 2013年 5-HT1A receptor agonist-mediated protection from MPTP toxicity in mouse and...
Finally, a 3 day regimen with the 5-HT 4 agonist RS 67333 was sufficient to reduce both the hyperlocomotion induced by olfactory bulbectomy and the diminution of sucrose intake consecutive to a chronic mild stress. These findings point out 5-HT 4 receptor agonists as a putative class of ...
Li, Antidepressant-like activity of YL-0919: A novel combined selective serotonin reuptake inhibitor and 5-HT1A receptor agonist, PLoS ONE 8... Hong-xia Chen,Zeng-liang Jin,Li-ming Zhang,... - 《Plos One》 被引量: 36发表: 2013年 Dual Inhibitors of Phosphodiesterase-4 and Serotonin ...
Serotonin is a monoamine neurotransmitter in the CNS and an endogenous5-HT receptor agonist. Serotonin also inhibits catechol O-methyltransferase (COMT), anenzymethat contributes to modultion the perception of pain, via non-competitive binding to the site bound by catechol substrates with a binding ...
only. In the case of 5-HT1A receptor ligands, full agonists, whether nonpreferential (flesinoxan, (±)8-OH-DPAT) or preferential for presynaptic receptors (F13714), showed the strongest activity in this model. The preferential presynaptic receptor partial agonist, S15535, was also active over...
Serotonin receptor subtypes are related to depression and also have been shown to be present in certain cells of the immune system. In the present report, we determined the presence of 5-HT1A receptors by the binding of the selective agonist 8-hydroxy-2-(di-n-propyl-amino)tetralin in ...
S4247 Prucalopride Succinate Prucalopride(R-108512) is a selective, high affinity 5-HT4 receptor agonist. The Ki values of prucalopride for human 5-HT(4a) and 5-HT(4b) receptor are 2.5 nM and 8 nM, respectively. Front Pharmacol, 2019, 10:1491 Front Pharmacol, 2018, 9:171 Neurogastro...