5-HTBiased agonistDrug discoverySerotoninNeurologyPsychiatrySerotonin 5-HT1Areceptor agonists are prime candidates for CNS drug discovery.The lack of specificity of classical agonists has long been a barrier to pharmacological progress.The recent concept of 5-HT1Abiased agonism implies targeting specific ...
Comparison of the Cardiovascular Effects of the 5-HT1A Receptor Agonist Flesinoxan with That of 8-OH-DPAT in the Rat Eur. J. Pharmacol., 180 (2) (1990), pp. 339-349 10.1016/0014-2999(90)90319-2 View in ScopusGoogle Scholar 41. Nalivaiko E., Ootsuka Y., Blessing W. W. Activati...
OBJECTIVE: To characterise the dual action of buspirone in stimulating the secretion of prolactin by blocking the 5-HT(1A) action with the 5-HT1A antagonist action of pindolol. METHODS: Healthy male subjects (n=35) received buspirone (0.5 mg x kg bw(-1) orally) with and without pre-treat...
The 5-HT1A receptor is a well-studied member of the serotonin receptor family, in part because of its role in regulating depression- and anxiety-like behavior4. However, the precise role of 5-HT1AR in the pathogenesis of depressive disorders and treatment of the diseases are not fully unders...
The serotonin 5-HT1A receptor agonist, 8-OH-DPAT (8-hydroxy-2-di-n-propylamino-tetralin), impairs retention performance in a passive avoidance learning task in rats. In the hippocampus of rats trained on this procedure and killed 1 h after the acquisitio
In 1980, buspirone was found to have anxiolytic potential. This finding initiated the development of the azapirones — highly serotonin 5-HT1A agonist
In an animal study, an increase of FC in the cortex, hippocampus, amygdala and dorsomedial thalamus was observed after giving 5-HT1A receptor agonist, 8-OH-DPAT14. These brain areas are known to express high levels of the 5-HT1A receptor15,16 and are involved in the frontal cortex-basal ...
5-HT ReceptorAutophagySerotonin Transporter ¥ 291 现货 规格 数量 客户已引用 Alverine citrate 枸橼酸阿尔维林, NSC 35459 T04285560-59-8 Alverine citrate (NSC 35459) 是5-HT1A 受体的拮抗剂,IC50值为101 nM,用于功能性胃肠道疾病。 5-HT Receptor ...
has a higher selectivity for 5-HT1Areceptors than the commonly used agonist, 8-OH-DPAT, it preferentially acts on post-synaptic receptors and has minimal effect on somatodendritic auto-receptors in raphe nuclei [23,24,25], allowing us to narrow down the brain regions and 5-HT1Areceptor subpopu...
Additionally 8-hydroxy-2-(di-n-propylamino)tetralin (DPAT), a 5-HT1A/7 receptor agonist also increased cGMP production. Stimulation of cGMP formation by DOM was prevented by a 5-HT2A/2C receptor antagonist, pirenperone, as well as by a 5-HT2A receptor selective antagonist, MDL100907. ...