A unique HCV RNA molecule is provided having an enhanced efficiency of establishing cell culture replication. Novel adaptive mutations have been identified within the HCV non-structural region that improves the efficiency of establishing persistently replicating HCV RNA in cell culture. This self-...
Some tentative steps along this road have previously been taken, but no one has been able to demonstrate that RNA replication could be self-propagating, that is, result in new copies of RNA that also could copy themselves.Now, however, two Scripps Research Institute scientists have taken a ...
RNA ReplicationRNA is replicated in the process of transcription of DNA, where mRNA (messenger RNA) is created through enzymatic catalysis of a polymerase complex reading the coding strand of a parent DNA sequence.Answer and Explanation: RNA, in modern organisms, does not necessarily self-replicate...
2001. Self-replicative RNA vaccines elicit protection against influenza A virus, respiratory syncytial virus, and a tickborne encephalitis virus. J. Infect... MN Fleeton,M Chen,B Peter,... - 《Journal of Infectious Diseases》 被引量: 135发表: 2001年 Replication-competent or attenuated, non...
Self-replicating RNA (srRNA) technology, in comparison to mRNA vaccines, has shown dose-sparing by approximately 10-fold and more durable immune responses. However, no improvements are observed in the adverse events profile. Here, we develop an srRNA vac
Self-replication of the RNA variant MNV-11 (86 base-pairs) by Qβ replicase leads, in the presence of salt, to stepwise selection of the more salt-resistant variants SV-11 (113 base-pairs) and MDV-1 (220 base-pairs). The structures of these and two other unrelated salt-resistant varia...
Introduction: Self-Replication, Fidelity, AndheredityChemical Systems Capable of Self-ReplicationPeptide Self-ReplicationNucleic AcidsNucleic Acid Self-ReplicationRNA Self-Replication: The RNA WorldCompartmentalization: Toward the Design of a Simple CellIn Vivo ReplicationMolecular Devices and AutomataConclusion ...
自复制RNA酶 TraceyA.LincolnandGeraldF.Joyce* 摘要：在RNA酶催化的RNA的RNA模板接合外，还存在一种两种酶以四个寡核苷酸 为基板催化彼此的合成。在没有蛋白质或其他生物材料的情况下，这些RNA酶通过交叉复制呈指数扩增。这种扩增的倍增时间约1小时，并可以继续下去。不同的交叉复制酶构建了不同的群体，并可以在...
中文: 胜的看法保持,自已复制是有机体或反对或充分有或整个地缺乏的能力。英文: “Replication is far from perfect.中文: 卫斯指出:「复制的情况很不理想。英文: RNA replication mechanism of nodaviruses中文: 野田村病毒RNA的复制机制 英文: The replication here is pretty accurate.中文: 复制这里是相当准确....
The RNA world hypothesis is founded on the idea of an RNA replicase, or self-replicating RNA molecule, and presupposes the later emergence of ribozymes cap... AJ Hager,JD Pollard,JW Szostak - 《Chemistry & Biology》 被引量: 135发表: 1996年 Replication of poliovirus RNA and subgenomic RNA...