Self-sustained replication of an RNA-enzyme. Science 323, 1229-1232.Lincoln TA, Joyce GF (2009) Self-Sustained Replication of an RNA Enzyme. Science 323:1229- 1232Lincoln, T.A., Joyce, G.F.: Self-sustained replication of an RNA enzyme. Sci- ence 323(5918), 1229-1232 (2009)...
自复制RNA酶 TraceyA.LincolnandGeraldF.Joyce* 摘要：在RNA酶催化的RNA的RNA模板接合外，还存在一种两种酶以四个寡核苷酸 为基板催化彼此的合成。在没有蛋白质或其他生物材料的情况下，这些RNA酶通过交叉复制呈指数扩增。这种扩增的倍增时间约1小时，并可以继续下去。不同的交叉复制酶构建了不同的群体，并可以在...
An RNA enzyme that catalyzes the RNA-templated joining of RNA was converted to a format whereby two enzymes catalyze each other's synthesis from a total of four oligonucleotide substrates. These cross-replicating RNA enzymes undergo self-sustained exponential amplification in the absence of proteins ...
M. Self-replication from random parts. Nature 437, 636 (2005). Article CAS Google Scholar Lincoln, T. A. & Joyce, G. F. Self-sustained replication of an RNA enzyme. Science 323, 1229–1232 (2009). Article CAS Google Scholar Wang, T. et al. Self-replication of information-bearing...
F. Self-sustained replication of an RNA enzyme. Science 323, 1229–1232 (2009). CAS PubMed PubMed Central Google Scholar Mills, D. R., Peterson, R. E. & Spiegelman, S. An extracellular Darwinian experiment with a self-duplicating nucleic acid molecule. Proc. Natl Acad. Sci. USA 58,...
A nuclease-resistant RNA enzyme, constructed entirely from L-ribonucleotides, was shown to undergo ligand-dependent, self-sustained replication with exponential growth. The catalytic motif is based on a previously described RNA ligase that can undergo either self- or cross-replication but had been li...
Most of the time the replicating enzymes would breed true, but on occasion an enzyme would make a mistake by binding one of the subunits from one of the other replicating enzymes. When such "mutations" occurred, the resulting recombinant enzymes also were capable of sustained replication, with ...
If an gene is used so often that the antimutagenic enzyme is used so often that it is likely to be mutated an antimutagenic enzyme can be implemented on the original antimutagenic enzyme, etc. etc. etc. In order to cure senility(you won’t go senile over hundreds of years if you ...
Fig. 2. Design of enzyme-responsive peptid nanomaterials: (a) Composition of enzyme-responsive peptide capsule n(BMP-2) and its use for bone repair [35]. (b) Peptide H autocatalyzed and self-assembled into hydrogels [36]. (c) MMP-responsive peptide vectors for enzyme-responsive drug releas...
The modeling studies indicate that the requirement for an optimum in the SR/PC ratio is a coupling between eGFP and T7 RNAP expression, whether through a shared resource or a shared enzyme. However, the increase of eGFP above the positive control during the self-regeneration phase requires a...