A significant problem of the origin of life is the emergence of cellular self-replication. In the context of the "RNA world", a crucial concern is how the RNA-based protocells could achieve the ability to produce their own membrane. Here we show, with the aid of a computer simulation, ...
Molecular structures and electrochemistry. Part I. {Fe(Cys)4} proteins. Coord. Chem. Rev. 257, 1777–1805 (2013). Article CAS Google Scholar Ball, R. & Brindley, J. Hydrogen peroxide thermochemical oscillator as driver for primordial RNA replication. J. R. Soc. Interface 11, 1–8 (...
Phase separation of mixtures of oppositely charged polymers provides a simple and direct route to compartmentalisation via complex coacervation, which may have been important for driving primitive reactions as part of the RNA world hypothesis. However, to date, RNA catalysis has not been reconciled wit...
Our work shows that RNA‐catalyzed RNA assembly can occur efficiently within prebiotically plausible fatty acid vesicles and represents a step toward the replication of primordial genomes within self‐replicating protocells.doi:10.1002/chem.202301376DasGupta, Saurja...
Elevated temperatures might have promoted the nucleation, growth, and replication of protocells on the early Earth. Recent reports have shown evidence that moderately high temperatures not only permit protocell assembly at the origin of life, but can have actively supported it. Here, the fast ...
self-assembly into stacked filaments, such as benzoyl cysteine. In this case, the oxidation reaction can be visualized by the appearance of stacked filaments, which further bundle into rigid fibrils that resemble a cytoskeletal network inside and around the coacervate droplets, demonstrating the Fe(...
Firstly, to investigate the catalytic activity of the Dz inside and outside the PCs, we used a self-reporting substrate (Subs-1) with an RNA linkage and a FRET pair (Cy5 and a black hole quencher (BHQ)) covalently attached at both ends. Upon Dz-catalyzed breaking of the RNA bond in ...
in autonomous entities, incorporating not only the machinery for product synthesis and energy generation, but also genomes, protein transcription and translation machinery and even the capacity for replication and cell division to create a true artificial life form capable of self-renewal (Figure 1a)....
If r was small, the first biological catalysts must have been polymerases, whereas if r was high (because non-enzymatic replication was intrinsically fast), then other kinds of catalysts that contribute to the synthesis of RNA and its precursors could have preceded polymerases. These scenarios are...
The implications are that if a replicase, that is a RNA that catalyzes its own replication, were present inside of a fatty acid vesicle, the resulting increased nucleic acid content would cause the vesicle to preferentially grow by acquiring fatty acids from non- replicase containing vesicles [26...