and differences in specificity among different antibodies to target different proteins [15,16]. In previous studies on radioimmunotherapy, cell-binding assays have been used as a useful technique to investigate the binding affinity of radiolabeled antibodies and to estimate tumor uptake in vivo [17]....
28, 33, 34 However the observations that in the skin, inhibition of either E-selectin or P-selectin alone dramatically reduces leukocyte recruitment raises the possibility that these two molecules are playing critical, yet nonoverlapping functions. Given that the types of leukocytes recruited by each...
GO terms enrichment analysis revealed a significant enrichment of various biological functions within genes over-transcribed in the Transflu-R line (Additional file 4A). Many enriched functions were related to P450 activity, including 'oxidoreductase activity', 'monooxygenase activity', 'heme binding' ...
We have shown previously that members of the TNF family of apoptosis-inducing proteins are substrates for this enzyme, resulting in increased death pathway signaling. The goal of the current study was to reconcile the proapoptotic and tumor-promoting functions of matrilysin. In the human HBL100 ...
The researchers tested their new sensor in two types of human cancer cells: one set that they knew was susceptible to a redox drug, and another that they knew was not susceptible. The sensor revealed that hydrogen peroxide levels were unchanged in the resistant cells but went up in the susce...
Carbohydrates — namely glycans — decorate every cell in the human body and most secreted proteins. Advances in genomics, glycoproteomics and tools from chemical biology have made glycobiology more tractable and understandable. Dysregulated glycosylatio
The selectins are a family of integral membrane proteins characterized by the presence of lectin-, epidermal growth fac- tor, and complement-binding domains (25, 26). L-selectin was previously known as LEC.CAM-1, LECAM-I, LAM I, and as the MEL-14, Leu-8, TQ1, and Dreg-56 antigen...
the set. Structure-based methods can also be used for template-free modeling [3–6] and model refinement procedures [7,8]. One weakness of high resolution structure-based methods, including protein free energy approximation functions [9–12] and physics based approaches [13,14], is their ...
The molecular mechanisms specifying patterns of gene expression in the vertebrate brain, which in turn determine the developmental fates of specific neurons, are yet to be clearly defined. Individual members of a recently identified family of transcriptional regulatory proteins, the GATA factors, are re...
The ability of Legionella to replicate inside protists and macrophages requires a complex Type IV-B secretion system (TFBSS) called the Icm/Dot system (Segal et al., 1998; Vogel et al., 1998), which delivers a repertoire of B300 effector proteins to host cells (Berger and Isberg, 1993;...