Table 3 Different types of TET3 binding proteins and their functions Full size table Classical functions of TETs TET1 Studies have shown the important role of TET1 in physiological functions, including development.70The deficiency of TET1 lowered female germ-cell numbers by controlling meiosis through ...
Nevertheless, together, these three studies on the proteome of two different ecotypes of Arabidopsis advance our knowledge on the nature and function of proteins present in the pollen grain at maturity. The proteome of Arabidopsis pollen is, however, not yet fully analyzed and further work is nee...
The expression profile of exosomal proteins is often significantly different in different types and stages of cancer, indicating that these proteins are closely associated with cancer development and progression6. Moreover, other functions of TD exosomes cannot be ignored, including their involvement in ...
Circular RNAs (CircRNAs) are single-stranded, covalently closed RNA molecules that are ubiquitous across species ranging from viruses to mammals. Important advances have been made in the biogenesis, regulation, localization, degradation and modification of circRNAs. CircRNAs exert biological functions by a...
The function of the tail-anchor sequence has been examined for Bim [26], [44] and Bik [45]. Other BH3-only proteins, such as Bid, Bad and Beclin-1 lack an identifiable tail-anchor sequence but contain other types of hydrophobic sequences. These sequences presumably target to the MOM ...
Microtubules (MTs) are one of the major types of filaments that constitute the eukaryotic cytoskeleton. Over the years, MTs have emerged as key players in cellular processes such as vesicle and organelle transport, DNA segregation during mitosis, cell migration and maintenance of cell polarity. Neur...
Tardigrade DNA protection is represented by 52 proteins of the molecular chaperone DNA J family: proteins of the DNA J family are classified into 3 types according to their structural domain decomposition. Type I J proteins compose of the J domain, a gly-rich region connecting the J domain ...
This mechanism employs several types of enzymes, the most important of which are the ubiquitin E3 ligases that catalyse the attachment of polyubiquitin chains to target proteins for their subsequent degradation by the 26S proteasome. Among the E3 families, the SCF is the best understood; it ...
and functions, we developed an approach allowing for medium-throughput analyses of MAPs in cell-free conditions using lysates of mammalian cells. Our pipeline allows for quantitative as well as ultrastructural analyses of microtubule–MAP assemblies. Analysing 45 bona fide and potential mammalian MAPs,...
addition, proteins involved in nuclear transport have been demonstrated to have nontransport functions, including roles in mitosis, regulation of transcription, and regulation of biomolecular condensates.6,7It is often possible to distinguish the contribution of canonical and noncanonical functions of NTPs...