This synergistic effect of spin and mTor supports the hypothesis that these two proteins cooperate to regulate female sexual receptivity. Discussion In this study, we identified two groups of neurons whose malfunction resulted in a significant decline in female sexual receptivity: a population of ...
Vaccine development targeting rapidly evolving pathogens such as HIV-1 requires induction of broadly neutralizing antibodies (bnAbs) with conserved paratopes and mutations, and in some cases, the same Ig-heavy chains. The current trial-and-error search f
However, characterization of this interaction is not straight forward as it is likely to involve multiple proteins and/or types of interaction. This work is an attempt to begin to understand the contribution of HCP sub‐populations and/or mAb interaction propensity to the variability in HCP levels...
submitting predictions for all 95 targets and achieved top results. The average difference in GDT-TS between models ranked first by SELECTpro and the most native-like model was 5.07. This GDT-TS difference was less than 1% of the GDT-TS of the most native-like model for 18 targets, and ...
The development of humanized monoclonal antibodies has continued to fuel the growth of the biotherapeutic market. Addressing the therapeutic demand for monoclonal antibodies has led to major improvements to the cell-based expression systems that are used to manufacture these proteins. Consequently, these...
This case series study examines the labeling of select dietary supplement products advertised as supporting or boosting the immune system for accurate
Carbohydrates — namely glycans — decorate every cell in the human body and most secreted proteins. Advances in genomics, glycoproteomics and tools from chemical biology have made glycobiology more tractable and understandable. Dysregulated glycosylation plays a major role in disease processes from immune...
Protein A/G is not as pH-dependent as Protein A alone, but otherwise has the additive properties of Protein A and G. Protein A/G binds nearly all isotypes and mammalian species of IgG from serum, ascites fluid, cell culture supernatant and other antibody samples, thereby enabling effective ...
Generalist bacterial predators are likely to strongly shape many important ecological and evolutionary features of microbial communities, for example by altering the character and pace of molecular evolution, but investigations of such effects are scarce. Here we report how predator-prey interactions alter...
The perception of odors from hosts is mediated via the chemosensory system of insects, which includes OBPs, chemosensory proteins, odorant receptors, ionotropic receptors, and sensory neuron membrane proteins [30,41]. The differences in host selection and odor sensitivity between maize and rice weevils...