A Survey of Deep Learning Methods in Protein Bioinformatics and its Impact on Protein Design Weihang Dai arXiv:2501.01477 The Promise of Protein Design: A Q&A with Nobel Laureate David Baker David Baker and Fay Lin GEN Biotechnology (2025) Protein design and structure solution for drug discovery ...
The charge state, hydrophobicity, conformation, and stability of a protein are all affected by various changes, which, in turn, influence its function. Protein modification has a variety of functions in different organs: (1) It ensure the fast and complex response of cells to regulate intra-...
we investigated the influence of biological sex on protein expression and its genetic regulation in 1,277 human brain proteomes. We found that 13.2% (1,354) of brain proteins had sex-differentiated abundance and 1.5% (150) of proteins had sex-biased protein quantitative trait...
Variation in the gene encoding dysbindin-1 (i.e., dystrobrevin-binding protein 1: DTNBP1) has frequently been associated with schizophrenia. Several studies have also found that dysbindin-1 gene and protein expression are altered in two affected brain ar
3m), and indole-3-glycerol phosphate synthase (IGPS; α/β; Fig. 3p) (Supplementary Table 1; see Methods for detailed calculations). Kinetic folding experiments showed that apoMb accumulates an early folding intermediate in which the A, B, G, and H helices are formed among its eight ...
The PiPooling layer first divides the edges into|\text {S}_{P}| \times |\text {S}_{L}|components, where\text {S}_{P}and\text {S}_{L}be atomic type(number) sets of the protein and its ligand, respectively. For the(T_k,T_l)-component, the pooling of edge representations is...
Trichomonas vaginalis is the most common nonviral sexually transmitted disease (STI) worldwide. Vaccination is generally considered to be one of the most effective methods of preventing infectious diseases. Using AP65, AP33 and α-actinin proteins, this
The low density lipoprotein receptor-related protein-deleted in tumor (LRP1B, initially referred to as LRP-DIT) was cloned and characterized as a candidate tumor suppressor. It is a new member of the low density lipoprotein receptor gene family. Its overall domain structure and large size (...
However, the specific types of lipids amenable to bicelle formation limit its applications as the lipid compositions in the membrane have been shown to influence the function of antimicrobial peptides and amyloid peptides [10], [15], [16]. The introduction of nanodiscs has provided a great ...
(d) Peptide sequence of the 58 kDa protein with 64% coverage (in bold). The sequence signal is highlighted in gray, the repeated PT domain is underlined, and the LPXTG motif is double-underlined. Based on its binding capacities (to hFg, this study; and to dermatan sulfate31,32), ...