很多慢性肾脏病(chronic kidney disease, CKD)都会进展为终末期肾病(end-stage kidney disease, ESKD),包括慢性肾小球肾炎、糖尿病肾病和多囊肾病。虽然我们通常无法治疗基础疾病,但大量实验动物研究和人体研究表明进行性CKD可能主要是由继发性因素导致,这些因素有时与初始疾病的活动性无关。这些因素包括全身性高血压和肾...
However, it is not clear how much glomerular hypertrophy leads to the formation of FSGS. We examined the association between glomerular diameter and FSGS lesions in chronic kidney disease (CKD) patients. Methods: We recruited 77 patients who underwent renal biopsy during 2016–2017; however, those...
Absence of hypoalbuminemia despite massive proteinuria in focal segmental glomerulosclerosis secondary to hyperfiltration 来自 onAcademic 喜欢 0 阅读量: 15 作者: M Praga,E Morales,JC Herrero,AP Campos,B Domínguez-Gil,R Alegre,J Vara,MA Martínez 展开 DOI: 10.1016/s0272-6386(99)70257-...
A kidney biopsy demonstrated focal segmental glomerulonephritis (FSGS). After confirming the diagnosis, she was treated with prednisolone 2 mg/kg/day for 1 month, leading to improved urine protein. Prednisolone was gradually tapered off, but the patient experienced worsening generalized edema and ...
chronic kidney diseaseglomerulosclerosisglomerulusparietal epithelialcellsprogressionrenalbiopsyParietal epithelial cells (PECs) are involved in the development of sclerotic lesions in primary focal and segmental glomerulosclerosis (FSGS). Here, the role of PECs was explored in the more common secondary FSGS ...
The plasma-soluble urokinase receptor levels, measured by commercial ELISA kits, of patients with primary FSGS (median: 2923, interquartile range 2205-4360 pg/ml) were significantly higher than those of patients with minimal change disease (median 2050 pg/ml), membranous nephropathy (median 2029 ...
The use of AAS can affect the kidneys and lead to a myriad of presentations, ranging from mildly elevated serum creatinine and blood urea nitrogen to irreversible chronic kidney disease and focal segmental glomerulosclerosis (FSGS). To the best of our knowledge, the coexistence of interstitial ...
end‐stage renal diseasefocal segmental glomerulosclerosiskidney transplantationnext‐generation sequencingrecurrenceTransplantation is the optimal modality for children with ESRD. High risk of disease recurrence and graft loss with FSGS, and its financial implications, may result in families refusing ...
Thus, plasma-soluble urokinase receptor levels did not differentiate primary and secondary FSGS, and although significantly elevated in FSGS, they showed considerable overlap with other glomerular diseases.Jing HuangGang LiuYi-Miao ZhangZhao Cui
stage renal diseasefocal segmental glomerulosclerosiskidney transplantationnext&8208generation sequencingrecurrenceBackground Transplantation is the optimal modality for children with ESRD. High risk of disease recurrence and graft loss with FSGS, and its financial implications, may result in families refusing ...