Yao J, Le TC, Kos CH, Henderson JM, Allen PG, Denker BM, Pollak MR: α-Actinin-4-mediated FSGS: An inherited kidney disease caused by an aggregated and rapidly degraded cytoskeletal protein. PLoS Biol 2 :787 –794,2004 [ PMC free article ] [ Pub...
目前人们对于FSGS仍有太多未知,即使是原发性FSGS,异质性也非常大,且FSGS的治疗存在诸多困境,包括频繁复发,激素依赖,激素抵抗和快速进展为终末期肾病(End stage kidney disease, ESKD)。南昌大学第二附属医院徐承云教授在本文中综述了遗传性FSGS的诊治进展。 FSGS的分类 根据病理组织形态分类的经典哥伦比亚分型法将FSGS分...
to determine whether the filtering capacity of the kidneys is impaired. The doctor may recommend ultrasound or an xray to see whether the shape or size of the kidneys is abnormal. I also had kidney biopsy. A biopsy may be helpful in confirming glomerular disease and identifying the cause. ...
These cells are the target of FSGS. One international "hot topic" in the research ofkidney diseaseis the discovery of the molecular causes of this condition, as a basis for developing a targeted form of therapy that is not yet currently available. "In around 20 per cent of cases of FSGS,...
ZHANG Jiong,WANG Jinquan National Clinical Research Center of Kidney Disease,Jinling Hospital,Nanjing Medical University, Nanjing 210016,China ABSTRACT Focal segmental glomerulosclerosis ( FSGS) is a common glomerular disease leading to end stage renal disease, and podocyte injury is the main cause of ...
APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases 2016, Proceedings of the National Academy of Sciences of the United States of America Pathogenesis of focal segmental glomerulosclerosis 2016, Journal of Pathology and Translatio...
α-Actinin-4-Mediated FSGS: An Inherited Kidney Disease Caused by an Aggregated and Rapidly Degraded Cytoskeletal Protein pFocal segmental glomerulosclerosis (FSGS) is a common pattern of renal injury, seen as both a primary disorder and as a consequence of underlying insults ... J Yao,TC Le,...
Recurrence of focal segmental glomerulosclerosis (rFSGS) after kidney transplantation is a cause of accelerated graft loss. To evaluate pathogenic antibodi... M Delville,TK Sigdel,C Wei,... - 《Science Translational Medicine》 被引量: 114发表: 2014年 Serum suPAR in patients with FSGS: trash or...
硕士学位论文低浓度他克莫司联合激素治疗特发性FSGS的回顾性对照研究刘宝莲指导教师赵洪雯副教授导师组成员彭侃夫教授、刘宏教授、张克勤教授培..
Focal segmental glomerulosclerosis (FSGS) is a major cause of pediatric kidney failure. Most cases of FSGS in children are idiopathic and have a high risk of post-transplantation recurrence and graft loss. Common treatments for recurrent FSGS (rFSGS) post-transplantation include plasmapheresis, immunoa...