INF2基因—编码肌动蛋白调节蛋白formin家族的一个成员,其突变最初是在2个常染色体显性遗传性FSGS大家族中发现。其受累家族成员活检证实FSGS、有终末期肾病(end-stage kidney disease, ESKD)或显著蛋白尿。INF2突变相关FSGS患者的发病年龄较晚(青春期或...
参考文献: 1. Kremers WK, Denic A, Lieske JC, et al. Distinguishing age-related from disease-related glomerulosclerosis on kidney biopsy: the Aging Kidney Anatomy study. Nephrol Dial Transplant 2015; 30:2034. 2. De Vriese AS, Sethi S, Nath KA, et al. Differentiating Primary, Genetic, and...
2. Haas M, Yousefzadeh N. Glomerular tip lesion in minimal change nephropathy: a study of autopsies before 1950. Am J Kidney Dis 2002; 39:1168. 3. Stokes MB, Markowitz GS, Lin J, et al. Glomerular tip lesion: a distinct entity within the minimal change disease/focal segmental glomerulosc...
参考文献: 1. Kremers WK, Denic A, Lieske JC, et al. Distinguishing age-related from disease-related glomerulosclerosis on kidney biopsy: the Aging Kidney Anatomy study. Nephrol Dial Transplant 2015; 30:2034. 2. De Vriese AS, Sethi S, Nath KA, et al...
Focal segmental glomerulosclerosis: Treatment of primary focal segmental glomerulosclerosis - UpTodate 问题 四 原发性 FSGS 何时不用免疫抑制剂 正确答案为B.、C、D、E 首先,判断原发性和继发性FSGS是非常重要的,因为这两种疾病的治疗方法截然不同。
Additionally, a hand search of UpToDate was conducted to glean further information about the best available evidence as summarized for clinician use. Relevant information was extracted and synthesized.Results: Primary FSGS and MCD result from distinct pathogenic mechanisms, hypothesized to involve kidney ...