Here, we show that SHARP1 is an unstable protein that is targeted for proteasomal degradation by the E3 ubiquitin ligase complex SCF beta TrCP. SHARP1 recruits beta TrCP via a phosphodegron encompassing Ser240 and Glu245 which are required for SHARP1 ubiquitylation and degradation. Furthermore, ...
beta-TrCP/E3RS (E3RS) is the F-box protein that functions as the receptor subunit of the SCF(beta-TrCP) ubiquitin ligase (E3). Surprisingly, although its two recognized substrates, IkappaB(alpha) and beta-catenin, are present in the cytoplasm, we have found that E3RS is located predomina...
SAG/ROC-SCF beta-TrCP E3 ubiquitin ligase promotes pro-caspase-3 degradation as a mechanism of apoptosis protection. Neoplasia 2006;8(12):1042-54.Tan M, Gallegos JR, Gu Q, Huang Y, Li J, Jin Y, Lu H, Sun Y (2006) SAG/ROC-SCF beta-TrCP E3 ubiquitin ligase promotes pro-caspase-3...
SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response. Mol Cell 2006;23:319-29.Peschiaroli, A (2006) SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response. Mol Cell 23: pp. 319-29...
Of particular importance is the identification of the E3 Ub-ligases because they confer substrate specificity to the pathways by directly binding to the target protein.;Our work has uncovered specific proteolytic pathways that regulate neuronal function and depend on the SCFbeta-TRCP E3 Ub-ligase ...
Identification of Small Non-Peptidic Ligands that Bind the Scf-beta-TRCP Ubiquitin Ligase to Target to ER for Ubiquitination and DegradationKathleen Sakamoto
Thus, betaTrCP-DEPTOR-mTOR intertwine to regulate cell survival and autophagy.Zhao YXiong XSun YMolecular cellZhao Y, Xiong X, and Sun Y (2011). DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(βTrCP) E3 ubiquitin ligase and regulates survival and autophagy. Mol Cell 44, ...
Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress. Mol Cell. 2006; 23 (3):307–318.Mailand N, Bekker-Jensen S, Bartek J, Lukas J. Destruction of Claspin by SCF βTrCP restrains Chk1 activation and facilitates recovery from ...
LinKunmingYangKunmingDigestive Diseases and SciencesHint1 up-regulates Ikappa Balpha by targeting the beta-Tr CP subunit of SCF E3 ligase in human hepatocellular carcinoma cells. Shi Z,Wu X,Ke Y,et al. Digestive Diseases and Sciences . 2016...
(2003). Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase. Dev. Cell 4 , 813-826.Margottin-Goguet F, Hsu JY, Loktev A, Hsieh HM, Reimann JD, Jackson PK.. Prophase destruction of Emi...