SAG/ROC-SCF beta-TrCP E3 ubiquitin ligase promotes pro-caspase-3 degradation as a mechanism of apoptosis protection. Neoplasia 2006;8(12):1042-54.Tan M, Gallegos JR, Gu Q, Huang Y, Li J, Jin Y, Lu H, Sun Y (2006) SAG/ROC-SCF beta-TrCP E3 ubiquitin ligase promotes pro-caspase-3...
beta-TrCP/E3RS (E3RS) is the F-box protein that functions as the receptor subunit of the SCF(beta-TrCP) ubiquitin ligase (E3). Surprisingly, although its two recognized substrates, IkappaB(alpha) and beta-catenin, are present in the cytoplasm, we have found that E3RS is located predomina...
GSK3, which can be inhibited by high PI3K via AKT-dependent inhibitory phosphorylation, phosphorylates the N-terminal phosphodegron in TAZ, and the phosphorylated TAZ binds to β-TrCP subunit of the SCFβ-TrCP E3 ubiquitin ligase, thereby leading to TAZ ubiquitylation and degradation. We observed ...
It involves an E1-E2-E3 enzymatic cascade to create a poly-Ub chain on the target protein. The ubiquitinated protein is then recognized by Ub-receptors, which facilitate its delivery to the 26S proteasome for degradation. With close to 700 dedicated proteins involved in the conjugation of Ub,...
Here, we show that SHARP1 is an unstable protein that is targeted for proteasomal degradation by the E3 ubiquitin ligase complex SCF beta TrCP. SHARP1 recruits beta TrCP via a phosphodegron encompassing Ser240 and Glu245 which are required for SHARP1 ubiquitylation and degradation. Furthermore, ...
DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(βTrCP) E3 ubiquitin ligase and regulates survival and autophagy. Mol Cell 44, 304-316.Zhao Y, Xiong X, Sun Y (2011) DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(bTrCP) E3 ubiquitin ligase and regulates ...
One class of E3 ligases is defined by the recently described SCF complexes, the archetype of which was first described in budding yeast and contains Skp1, Cdc53, and the F-box protein Cdc4. These complexes recognize their substrates through modular F-box proteins in a phosphorylation-dependent...
KunmingYangKunmingDigestive Diseases and SciencesHint1 up-regulates Ikappa Balpha by targeting the beta-Tr CP subunit of SCF E3 ligase in human hepatocellular carcinoma cells. Shi Z,Wu X,Ke Y,et al. Digestive Diseases and Sciences . 2016...
Shi, ZhitianWu, XuesongKe, YangWang, LinDigestive Diseases and SciencesHint1 up-regulates Ikappa Balpha by targeting the beta-Tr CP subunit of SCF E3 ligase in human hepatocellular carcinoma cells. Shi Z,Wu X,Ke Y,et al. Digestive Diseases and Sciences . 2016...