Of particular importance is the identification of the E3 Ub-ligases because they confer substrate specificity to the pathways by directly binding to the target protein.;Our work has uncovered specific proteolytic pathways that regulate neuronal function and depend on the SCFbeta-TRCP E3 Ub-ligase ...
Here, we show that SHARP1 is an unstable protein that is targeted for proteasomal degradation by the E3 ubiquitin ligase complex SCF beta TrCP. SHARP1 recruits beta TrCP via a phosphodegron encompassing Ser240 and Glu245 which are required for SHARP1 ubiquitylation and degradation. Furthermore, ...
Zhao Y, Xiong X, Sun Y (2011) DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(betaTrCP) E3 ubiquitin ligase and regulates survival and autophagy. Mol Cell 44(2):304–316DEPTOR, an mTOR Inhibitor, Is a Physiological Substrate of SCF(βTrCP) E3 Ubiquitin Ligase and ...
Shi, ZhitianWu, XuesongKe, YangWang, LinDigestive Diseases and SciencesHint1 up-regulates Ikappa Balpha by targeting the beta-Tr CP subunit of SCF E3 ligase in human hepatocellular carcinoma cells. Shi Z,Wu X,Ke Y,et al. Digestive Diseases and Sciences . 2016...
LinKunmingYangKunmingDigestive Diseases and SciencesHint1 up-regulates Ikappa Balpha by targeting the beta-Tr CP subunit of SCF E3 ligase in human hepatocellular carcinoma cells. Shi Z,Wu X,Ke Y,et al. Digestive Diseases and Sciences . 2016...