b-TRCP is one of the 69 F-box proteins that form the SCF (Skp1-Cullin-1-F-box protein) type of E3 ligase complexes. Notably, the SCF complex is composed of Skp1, Cullin-1, Ring box protein-1 (Rbx1)/Roc1 and one of the 69 F-box proteins. SCFb-TRCP often targets substrates ...
scfb trcp e3 ubiquitin 1igase targets the tumor suppressor znrbeta for ubiquitination and degradationWnt signaling has emerged as a major regulator of tis- sue development by governing the self-renewal and maintenance of stem cells in most tissue types. As a key upstream regulator of the Wnt ...