Pagano, SCF ubiquitin ligase-targeted therapies. Nat. Rev. Drug Discov. 13, 889-903 (2014).Skaar JR, Pagan JK, Pagano M. SCF ubiquitin ligase- targeted therapies. Nature reviews Drug discovery. 2014; 13:889-903.Skaar JR, Pagan JK, Pagano M (2014) SCF ubiquitin ligase-targeted therapies...
SCF ubiquitin ligase-targeted therapies. Nat Rev Drug Discov 13, 889–903 (2014). https://doi.org/10.1038/nrd4432 Download citation Published14 November 2014 Issue DateDecember 2014 DOIhttps://doi.org/10.1038/nrd4432 Subjects Cancer Drug discovery Immunological disorders Ubiquitin ligases This ...
In one specific example, the UbV binds to the interface of Skp1 and F-box proteins and thereby prevents Cul1 binding to the same surface and inhibits SCF E3 ligase activity by disrupting complex formation. SCF E3 ligases that can be targeted by the UbVs of the invention include those ...
Ewing sarcoma (ES) is an aggressive bone and soft tissue tumor of children and young adults in which finding effective new targeted therapies is imperative... C Mackintosh,DJ García-Domínguez,J L Ordóez,... - 《Oncogene》 被引量: 54发表: 0年 DNA-Damage Control: Claspin Destruction Turns...
Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy. Cancer Cell 2014; 25: 91–101. 10 Deshaies RJ, Joazeiro CAP. RING domain E3 ubiquitin ligases. Annu Rev Biochem 2009; 78: 399–434. 11 Emanuele MJ, Elia AEH, Xu Q, Thoma CR, Izhar L, Leng Y et al...
(2014) SCF ubiquitin ligase-targeted therapies. Nat Rev Drug Discov 13, 889-903Skaar JR, Pagan JK and Pagano M: SCF ubiquitin ligase- targeted therapies. Nat Rev Drug Discov 13: 889-903, 2014.Skaar, J. R., Pagan, J. K., and Pagano, M. (2014) SCF ubiquitin ligase- targeted ...
It is known that some components within the SCF apparatus are targeted by the ubiquitin ligase anaphase-promoting complex or by auto- ubiquitylation within their own SCF complex.17,18 Recent studies also show that one F-box protein may target another F-box protein for ubiquitylation to mediate ...
(Fig.3g, h), indicating that Brg1, as an ubiquitin substrate of FBW7, was upregulated in gastric cancer in part due to decreased FBW7 expression that subsequently resulted in compromised enzymatic activity of the SCFFBW7E3 ligase complex. These data further suggested that Brg1, as a downstream...