SCF ubiquitin ligase-targeted therapies. Nat Rev Drug Discov 13, 889–903 (2014). https://doi.org/10.1038/nrd4432 Download citation Published14 November 2014 Issue DateDecember 2014 DOIhttps://doi.org/10.1038/nr
Pagano, SCF ubiquitin ligase-targeted therapies. Nat. Rev. Drug Discov. 13, 889-903 (2014).Skaar, J. R., Pagan, J. K., and Pagano, M. (2014) SCF ubiquitin ligase-targeted therapies. Nat Rev Drug Discov 13, 889-903Skaar JR, Pagan JK, Pagano M (2014). SCF ubiquitin ligase-...
Ubiquitin signaling in cell cycle control and tumorigenesis 2021, Cell Death and Differentiation Show abstract SCF ubiquitin ligase-targeted therapies 2014, Nature Reviews Drug Discovery Roles of F-box proteins in cancer 2014, Nature Reviews Cancer Mechanisms and function of substrate recruitment by F-...
In one specific example, the UbV binds to the interface of Skp1 and F-box proteins and thereby prevents Cul1 binding to the same surface and inhibits SCF E3 ligase activity by disrupting complex formation. SCF E3 ligases that can be targeted by the UbVs of the invention include those ...
It is known that some components within the SCF apparatus are targeted by the ubiquitin ligase anaphase-promoting complex or by auto- ubiquitylation within their own SCF complex.17,18 Recent studies also show that one F-box protein may target another F-box protein for ubiquitylation to mediate ...
Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase. Mol Cell. 2003;11:1445–56. 53. Cheng C, Huang Z, Zhou R, An H, Cao G, Ye J, et al. Numb negatively regulates the epithelial-to-...
related and tumor-related factors and expert guidelines recommend enrollment in a clinical trial for the majority of patients who will ultimately fail approved therapies.The Skp1-Cul1-F-box protein (SCF) ubiquitin ligase SCFSkp2 promotes ubiquitination and degradation of the cell-cycle inhibitor p27...
Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase. Mol Cell. 2003;11:1445–56. 53. Cheng C, Huang Z, Zhou R, An H, Cao G, Ye J, et al. Numb negatively regulates the epithelial-to-...
(Fig.3g, h), indicating that Brg1, as an ubiquitin substrate of FBW7, was upregulated in gastric cancer in part due to decreased FBW7 expression that subsequently resulted in compromised enzymatic activity of the SCFFBW7E3 ligase complex. These data further suggested that Brg1, as a downstream...