表格翻译自https://www.ecdc.europa.eu/en/covid-19/variants-concern 从表中可以看出Omicron刺突蛋白中感兴趣的突变位点爆炸级增多,表格填不下了。 Omicron刺突蛋白中积累了30多个突变,这是感染的初始步骤的关键。这或许可以解释为什么欧米克隆疫苗逃避免疫的能力更强,导致再次感染的风险比以前的变种疫苗更高(高5.4...
While mutations are common in RNA viruses and mostly will not make a significant difference, some mutations proved to provide SARS-CoV-2 with a selective advantage, such as increased transmissibility or increased escape from specific antibodies4,5,6,7,8. Those variants with proven or suspected im...
In the last box, the x-axis and y-axis represent mutations on the RBD and a timeline of COVID-19 variants and vaccinations, respectively. The cylindrical plot illustrates the breadth of the BCR repertoire following vaccination. The red dots represent SARS-CoV-2 variants. NT nucleotides, AA ...
This review highlights the SARS-CoV-2 variants in Bangladesh and the timeline of their detection in the context of the global experience with the management of vaccination and natural SARS-CoV-2 infection. The motivation to overcome the COVID-19 vaccine dilemma and track Bangladesh...
(A) ELISA curves of the RBD variants binding to human ACE2. Shown are the binding curves calculated with nonlinear regression to the arithmetic mean values from eight replicates ± SEM. The calculated steady-state KD values ± SEM from end-point ELISA measurements and the fold-change in compar...
Fig. 4. Timeline of earliest reports of SARS-CoV-2 VOCs reported to date. To date, studies investigating the various SARS-CoV-2 variants have been heavily focused on the mutations within the S protein due to its role in viral entry and transmission, and its role as a target for antibody...
SARS-CoV-2, which has a higher morbidity and fatality rate, appeared at the end of 2019, followed by the emergence of a variety of variants, and the transmission and infection capacity of SARS-CoV-2 has been enhanced. HCoV-OC43 may be similar to SARS-CoV-2 in terms of genomic ...
Further research is warranted to understand the interplay between natural and vaccine-induced immunity and the role of exposure to specific variants and the interval between exposures (vaccination doses and infection). The need for further booster doses should take into consideration both vaccine dos...
The constant emergence of SARS-CoV-2 variants continues to impair the efficacy of existing neutralizing antibodies, especially XBB.1.5 and EG.5, which showed exceptional immune evasion properties. Here, we identify a highly conserved neutralizing epitope
Neutralising reactivity against SARS-CoV-2 Delta and Omicron variants by vaccination and infection history Enrico Lavezzo Monia Pacenti Andrea Crisanti Genome Medicine(2022) Associated content Collection COVID-19 Collection 2021 Top 25 COVID-19 Articles ...