was first reported in Wuhan (China) and has rapidly disseminated around the globe [1]. Only one year after the pandemic outbreak, scientists have developed efficient vaccines andpromisingtherapeutic interventions, such as monoclonal antibodies (mAbs). However,SARS-CoV-2 variantsaccumulating mutations...
Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7. Nature 593, 130–135 (2021). Article CAS PubMed Google Scholar Chen, R. E. et al. Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies. Nat. Med. 27, 717–726 (2021...
Wildlife reservoirs of broad-host-range viruses have the potential to enable evolution of viral variants that can emerge to infect humans. In North America, there is phylogenomic evidence of continual transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from humans to white-...
10. Baum A., et al. Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies.Science. 2020;369(6506):1014-1018. 11. Liu Z., et al. Landscape analysis of escape variants identifies SARS-CoV-2 spike mutations that attenuatemonoclonaland ser...
seen during previous Covid-19 waves, an observation that some members of a weary public are understandably eager to ascribe to an intrinsic tendency of this variant to cause less severe illness. Even more than for previous variants, ho...
The virus SARS-CoV-2 has forced human cells to copy its genetic code innumerable times over the past couple of years, and, in the process, errors have emerged. These errors, or mutations, are the raw material for new variants. Scientists have found that nearly half of the genetic sequence...
There is a growing concern that these new variants could impair the efficacy of current monoclonal antibody (mAb) therapies or vaccines. This is mainly because many of the mutations reside in the antigenic supersite in NTD16,17 or in the ACE2-binding site (also known as the RBM) which is...
Over the course of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, the clinical, scientific, and public health communities have had to respond to new viral genetic variants. Each one has triggered a flurry of media attention, a range of reactions from the scientific ...
The mutation rate is the value at which the base pair or a larger region of DNA changes are made during the genome replication. Understanding the rate of mutation is of fundamental importance because the rate of mutations has explained the emergence of new SARS-CoV-2 variants and their establi...
these NPIs were not sufficient for controlling the growth of the variant, leading to a doubling of the death incidence in January 2021 and the necessity of further stringent restrictions. This suggests that new variants with an increased fitness are particularly dangerous when in-place NPI only mar...