参考资料: Paul Elliott et al. Exponential growth, high prevalence of SARS-CoV-2, and vaccine effectiveness associated with the Delta variant. Science, 2021, doi:10.1126/science.abl9551.
11. MordaniS. Coronavirus: Delta Plus is now a variant of concern in India 2021[cited 2021 Jun 26]. Available from:https://www.indiatoday.in/coronavirus-outbreak/story/covid-delta-plus-variant-declared-variant-of-concern-in-india-sources-1818121-2021-06-22?utm_source=izooto&utm_medium=pus...
8Current vaccines have been found to be highly effective against the Delta variant, particularly in preventing severe and critical disease, although their effectiveness is somewhat lower compared with their effectiveness against ...
背景 2021年11月,南非出现SARS-CoV-2奥密克戎(omicron)关切变异株(variant of concern),这与COVID-19病例数的增加有关。本研究以Thermo Fisher Scientific TaqPath COVID-19 PCR检测中的S基因靶标失效(SGTF)作为指标,评估omicron变异株感染的临床严重程度。 方法 本研究把南非国家的COVID-19病例数据、SARS-CoV-...
SARS-CoV-2 delta variant: a persistent threat to the effectiveness of vaccinesdoi:10.1016/S1473-3099(21)00697-6Ramachandran ThiruvengadamAkshay BinaykeAmit AwasthiThe Lancet Infectious Diseases
The SARS-CoV-2 Delta variant has become the dominant strain worldwide. It is around twice as transmissible as its ancestral strain, with a shorter incubation period and higher viral load during infection. Now, Bing Chen and colleagues show that mutations in spike protein of Delta allow for ...
The SARS-CoV-2 Delta (Pango lineage B.1.617.2) variant of concern spread globally, causing resurgences of COVID-19 worldwide1,2. The emergence of the Delta variant in the UK occurred on the background of a heterogeneous landscape of immunity and relaxati
然后,将结合亲和力预测细分为SARS-CoV-2 VOC亚组,包括Alpha(N501Y)、Beta(K417N + E484K + N501Y)、Delta(L452R + T478K)和Eta(E484K),以野生型(WT)SARS-CoV-2为参考。结果表明,AI对评估S蛋白突变对ACE2结合的影响是准确的,所有四个变体的PCC在0.78到0.86之间。本文使用文献中的报道数据...
Figure 1. Non-RBM antibodies conferresistance against the SARS-CoV-2 Omicron variant 2、双特异性单域抗体bn03的设计 因为Omicron由于突变产生了免疫逃逸,为了增加抗体中和效果,一个手段是可以同时使用多个针对不同表位的抗体,另一种方法就是构建双特异性抗体。所以这篇文章,接下来作者他们就选择了构建高效的双特...
SARS-CoV-2引起的COVID-19已成为全球的重大公共卫生事件,尽管 SARS-CoV-2 疫苗已在全球范围内广泛使用,但并非所有个体都能产生中和抗体,尤其是Delta(δ) 和 Omicron 变种的出现对目前SARS-CoV-2疫苗的有效性提出了严峻挑战,因此开发...