Acute infection or COVID-19 represents the initial illness period following SARS-CoV-2 infection and is the best characterized of the 3 illness periods. The onset of COVID-19 signs or symptoms (eg, cough, fever, dyspnea) is associated with viral replication and initial host immune response.5...
In just over 2 years, SARS-CoV-2 has infected 500 million people, causing more than 6 million COVID-19 deaths. High infection rates have provided substantial opportunities for the virus to evolve, as variants with enhanced transmissibility, pathogenesis, and resistance to neutralizing antibodies hav...
While mutations are common in RNA viruses and mostly will not make a significant difference, some mutations proved to provide SARS-CoV-2 with a selective advantage, such as increased transmissibility or increased escape from specific antibodies4,5,6,7,8. Those variants with proven or suspected im...
The changes in effective reproductive number (denoted as Re) of the Alpha and Delta variants of SARS-CoV-2 virus in Cambodia were estimated using BEAST 2 v.2.6.637. The estimates of Rerepresent the average number of secondary infections caused by an infected individual in a population, which...
Tracking the emergence, introduction and spread of SARS-CoV-2 variants of concern are essential for informing public health strategies. In 2021, Cambodia faced two major epidemic waves of SARS-CoV-2 triggered by the successive rise of the Alpha and Delta
SARS-CoV-2系谱上的这个巨大的分支一天突然出现,没有任何警告或迹象表明它正在生长。一种可能性是,这个分支确实随着时间缓慢生长,但由于某种未知的原因,科学家们看不到它。也许是因为病毒在另一种动物体内进化,比如啮齿动物,然后又回到了人类体内。也许是因为病毒在一个患有慢性感染的人体内进化得非常快。或者可能是...
New variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged, imposing the need for periodic booster doses. However, whether booster doses should be applied to the entire population or groups, and the booster doses interval, remains unclear. In this study, we eval...
Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue to emerge and evade immunity, resulting in breakthrough infections in vaccinated populations. There is an urgent need for the development of vaccines with broad protective
1 and Supplementary Tables 1 and 2). The patients tested positive for SARS-CoV-2 by quantitative PCR with reverse transcription (RT–qPCR; Ct ≤ 35) during late pregnancy (31.6–39.6 weeks). Among the patients, six displayed mild symptoms and one had severe symptoms, requiring ...
The constant emergence of SARS-CoV-2 variants continues to impair the efficacy of existing neutralizing antibodies, especially XBB.1.5 and EG.5, which showed exceptional immune evasion properties. Here, we identify a highly conserved neutralizing epitope targeted by a broad-spectrum neutralizing antibody...