Haozheng Cai, Baoren Tu, Jing Ma, Limin Chen, Lei Fu, Yongfang Jiang, Quan Zhuang DOI: 10.12659/MSM.924171 Med Sci Monit 2020; 26:e924171 17559 729 0 13 Apr 2020 : Special report Public Health Interventions to Mitigate Early Spread of SARS-CoV-2 in Poland Jarosław Pinkas, ...
Here, we used mouse-adapted SARS-CoV-2 strain MA10 to investigate the role of adaptive immune cells in disease. We found that while infected wild-type mice lost ~10% weight by 3 to 4 days postinfection, rag/ mice lacking B and T lymphocytes did not lose weight. Infected lungs at ...
SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagywww.pubcard.net/paper/5502b01e4bf74476b74473dce46b5866 李兴宇 Xingyu Li ¹, 侯佩莉 Peili Hou ¹, 马文青 Wenqing Ma ¹,王雪峰Xuefeng Wang ², 王洪梅 Hongmei Wang ¹, Zhangping Yu ...
新型冠状病毒(S A R S ＧC o V Ｇ２ )变异的研究进展蒋潘虹１,２ ,阮嘉雯２,俞慕华２,卢次勇１ 深圳市 医疗卫生三名工程 引进高层次医学团队项目(N o ．S Z S M ２０１８０３０８１)㊁深圳市南山区２０２０年科技计划项目(医疗卫生类)和深圳市南山区医学重点学科项目(病原生物学)联合资助通讯作者:俞...
administered with single dose of 1 or 0.1 mg/kg of aRBD-2-5-Fc followed by intratracheal inoculation with 1 × 105 PFU of the MA10. Animals mock-treated with PBS were set as controls (Fig. 4a). As shown in Fig. 4d, the control animals rapidly lost on average of 12.2% of ...
Hoeve MA, Nash AA, Jackson D, Randall RE, Dransfield I. Influenza virus A infection of human monocyte and macrophage subpopulations reveals increased susceptibility associated with cell differentiation. PLoS ONE. 2012;7(1):29443. Article CAS Google Scholar Michlmayr D, Andrade P, Gonzalez K, ...
不能判定病毒是否能够复制,无法评估样品是否具有感染性.基于细胞培养的病毒分离是评估样品是否具有潜在感染性的经典方法,考虑到生物安全等因素,该方法不适合在基层实验室广泛推广.本文总结了目前报道的评估S A R S ＧC o V Ｇ２病毒样品感染性的方法并分析其优缺点.以期建立标准化且简单易行适合广泛开展的替代方法,...
mainly the membrane form of the intercellular adhesion molecule-1 (ICAM-1) that is expressed in nasal and bronchial epithelial cells [9]. This interaction has been demonstrated to regulate differently the two soluble and membrane-bound forms, suggesting a different role during the infection [10]....
Approximately 2 g of tissue was placed into a 50 mL conical tube containing 10 mL TRIzol reagent (Thermo Fisher Scientific, Waltham, MA) and kept at −80 °C. All samples were thawed at room temperature in TRIzol reagent for 10 min to sterilize any SARS-CoV-2 infected sample...
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