Schematic Diagram of SARS-CoV Genome Indicating Mutations Found in MA15 VirusAnjeanette, RobertsDamon, DemingChristopher, D PaddockAaron, ChengBoyd, YountLeatrice, VogelBrian, D HermanTim, SheahanMark, HeiseGillian, L Genrich
15 Apr 2020 : Clinical Research Psychological Impact and Coping Strategies of Frontline Medical Staff in Hunan Between January and March 2020 During the Outbreak of Coronavirus Disease 2019 (COVID‑19) in Hubei, China Haozheng Cai, Baoren Tu, Jing Ma, Limin Chen, Lei Fu, Yongfang Jiang...
Histopathological Changes in Lungs from SARS-CoV (Urbani)–Infected and MA15-Infected Mice (Hematoxylin and Eosin Stain, Original Magnifications ×25)Anjeanette, RobertsDamon, DemingChristopher, D PaddockAaron, ChengBoyd, YountLeatri...
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA Chuangqi Wang, Tomer Zohar & Douglas A. Lauffenburger Massachusetts General Hospital Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Boston, MA, USA Andrea G. Edlow Massachusetts ...
i d e m i cP e r i o d s G U OJ i n g j i n g １,Y A N G D i ２,L I U Y a n a n １,L IW e i j i e １,F A N G Q i a n １,F A N G W e i １,MA X u e y i n g １(１．D e p a r t m e n t o fC l i n i c a l L a b...
Assay was validated using boceprevir, a known covalent inhibitor for the SARS-CoV-2 3CLpro (Fu et al., 2020; Ma et al., 2020). Using the same experimental condition, we screened the niclosamide derivative library at compound concentration of 100 μM. Among them, JMX0286, JMX0301 and JMX...
Erickson MA, Banks WA. Age-associated changes in the immune system and blood–brain barrier functions. Int J Mol Sci. 2019;20(7):1632. Article CAS PubMed Central Google Scholar Singh I, Sagare AP, Coma M, Perlmutter D, Gelein R, Bell RD, et al. Low levels of copper disrupt brain...
不能判定病毒是否能够复制,无法评估样品是否具有感染性.基于细胞培养的病毒分离是评估样品是否具有潜在感染性的经典方法,考虑到生物安全等因素,该方法不适合在基层实验室广泛推广.本文总结了目前报道的评估S A R S ＧC o V Ｇ２病毒样品感染性的方法并分析其优缺点.以期建立标准化且简单易行适合广泛开展的替代方法,...
Yuan L, Zhou M, Ma J, Liu X, Chen P, Zhu H, et al. Dexamethasone ameliorates severe pneumonia but slightly enhances viral replication in the lungs of SARS-CoV-2-infected Syrian hamsters. Cell Mol Immunol. 2022;19:1–3. https://doi.org/10.1038/s41423-021-00793-7. Article CAS Google...
BALB/c和C57BL/6N小鼠第3次加强免疫后2周采集小鼠血清,检测SARS-CoV-2中和抗体水平,检测结果显示:BALB/c小鼠平均中和抗体效价达1:830(图14),C57BL/6N小鼠平均中和抗体效价达1:338(图15)。 实验结果表明,BLP疫苗诱导了抗BMA8和C57MA14的中和抗体应答,可以100%保护老龄BALB/c和C57BL/6N小鼠抵抗小鼠适应性SARS...