SARS-CoV-2 is an extremely contagious respiratory virus causing adult atypical pneumonia COVID-19 with severe acute respiratory syndrome (SARS). SARS-CoV-2 has a single-stranded, positive-sense RNA (+RNA) genome of ~ 29.9 kb and exhibits significant genetic shift from different isolates. Afte...
The outbreak of COVID-19 has brought great threat to human health. Its causative agent is a severe acute respiratory syndrome-related coronavirus which has been officially named SARS-CoV-2. Here we report the discovery of extremely low CG abundance in it
SARS-CoV-2 has a large and complex positive chain RNA genome of approximately 30,000 nucleotides in length that encodes known and hypothetical proteins6. Much of the viral genome corresponds to a large open reading frame (ORF), called ORF1ab. This gene encodes a polyprotein which, when clea...
If a virus strain among all sequenced viruses has many descendants in the genome set, this strain is conferred with high transmissibility. Therefore, the SNP mutations in this strain are critical for increased transmissibility. The directed Jaccard distances of the SNP mutations are used to identify...
Mutation rate in the SARS-CoV-2 genome The mutation rate is the value at which the base pair or a larger region of DNA changes are made during the genome replication. Understanding the rate of mutation is of fundamental importance because the rate of mutations has explained the emergence of ...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the coronavirus disease 2019 (COVID-19) pandemic, has resulted in > 23,000,000 infections and > 800,000 deaths [1], [2]. SARS-CoV-2 is highly contagious and induces serious multi-organ damages [3], [4], ...
as we were designing the library prep and sequencing strategy for the SARS-CoV-2 viral genome sequencing, we sought to use specific baits to fish out this viral genome from our samples. IDT has been an invaluable partner in this research effort to ‘capture’ this viral genome, accelerating ...
A large part of fighting against the SARS-CoV-2 pandemic is the practice of contact tracing, where the whereabouts of an infected person can be traced and anyone who has been in contact with that person over the past days tested for COVID-19. While smartphone apps have been a popular cho...
We show that the mutant N protein-containing R203K and G204R changes has higher oligomerization and stronger viral RNA-binding ability, suggesting a potential link of these mutations with efficient viral genome packaging. The R203K and G204R mutations are in close proximity to the recently report...
Mpro crystallizes in a ligand-free form that diffracts to near-atomic resolution We report the apo structure of SARS-CoV-2 Mpro with data to 1.25 Å. The construct we crystallised has native residues at both N- and C--terminals, without cloning truncations or appendages which could ...