别名 SARS-CoV-2 spike protein; 2019-nCOV Spike protein; Spike glycoprotein; Spike protein S1; Surface glycoprotein; Spike protein RBD; SPIKE_SARS2; 2019-nCOV Spike RBD (K417N、E484K、N501Y), Recombinant (His Tag); Recombinant SARS-Cov-2 Spike RBD protein (E417N, E484K, N501Y), His 突...
Most of the ongoing projects aimed at the development of specific therapies and vaccines against COVID-19 use the SARS-CoV-2 spike (S) protein as the main target. The binding of the spike protein with the ACE2 receptor (ACE2) of the host cell constitutes the first and key step for vir...
In contrast, single mutation E484K had almost no impact on the binding kinetics, but essentially abolished recognition of RBD by convalescent sera. Interestingly, combining mutations E484K, K417N and N501Y resulted in a RBD with both features: enhanced receptor binding and abolished immune ...
英文名: SARS-CoV-2 Spike RBD Protein (K417N & E484K & N501Y, hFc)描述: The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl ...
與該出版物相關的檢測方法,一種用於檢測 SARS-CoV-2 變異體, 快速監測循環變異,監測具有生物學意義的突變,以及早期檢測緊急變異體,例如 E. Lai, D. Becker 等科學家對Omicron的檢測,,具體請看下方標藍的內容。 由於檢測引物和探針序列 (S477N, T478K, Q...
Spike mutations in SARS-CoV-2 variants have gained more attention because of the association with changes in viral characteristics [5]. Significant spike mutations (D614G, E484K, K417N/T, N501Y, L452R, T478K) are found associated with different clinical consequences throughout the globe [6]...
SARS-CoV-2; COVID-19; spike glycoprotein; mutation; genetic variation; ACE2; variants; immune escape; transmissibility1. Introduction The recently identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the pandemic of coronavirus disease 2019 (COVID-19), which ...
Note:Combinations of N501Y, K417N/T, L452R, and E484K/A are found in three of the four current VOCs (Beta, Gamma, Omicron). It is likely that these mutations became rapidly selected owing to their contribution to enhanced SARS-CoV-2 fitness [8, 10]. ...
The study suggests that SARS-CoV-2 genomes from India share consensus with global trends with respect to D614G as most prevalent mutational event (81.66% among 2525 Indian isolates). Indian isolates did not reported prevalence of N439K mutation in receptor binding motif (RBM) as compared to ...
A variant is a group of coronaviruses that share the same lineage of mutation. If enough mutations accumulate in a lineage, it might change the way the variant functions. These lineages are known as strains. Consequently, COVID-19 is caused by a coronavirus strain known as SARS-Co...