The structure of CmoA, a member of the SAM-dependent methyltransferase superfamily, revealed a ligand consistent with Cx-SAM in the catalytic site. Mechanistic analyses showed an unprecedented role for prephenate as the carboxyl donor and the involvement of a unique ylide intermediate as the carboxyl...
1 Topology diagram of EpeE, radical SAM binding motifs and coordination of SAM in EpeE and representative members of the radical SAM enzyme superfamily. a, EpeE topology diagram showing a truncated α5/β6 TIM barrel in the radical SAM domain and T-SPASM domain with a single AuxI cluster. ...
Sam68 has also been documented as a Cyclic Adenosine Monophosphate-Response-Element-Binding protein (CREB)-Binding Protein (CBP) binding partner which can repress abrupted Wnt/β-catenin signaling. As a result, Sam68 has been identified as a selective target and mediator of Wnt/β-catenin regula...
Chromosomal location and cloning of the gene (trmD) responsible for the synthesis of tRNA (m1G) methyltransferase in Escherichia coli K-12 Mol. Gen. Genet. MGG, 188 (3) (1982), pp. 440-446 CrossrefView in ScopusGoogle Scholar [151] L. Droogmans, H. Grosjean Enzymatic conversion of gu...
et al. Thiostrepton tryptophan methyltransferase expands the chemistry of radical SAM enzymes. Nat. Chem. Biol. 8, 957–959 (2012). Article CAS PubMed Google Scholar Blaszczyk, A. J. et al. Spectroscopic and electrochemical characterization of the iron-sulfur and cobalamin cofactors of TsrM, ...
DNA methyltransferase can increase plant stress resistance by modulating methylation levels of a few typical stress-resistance genes [32], [33]. In this study, association analysis identified genes associated with DMR that were involved in salt stress response and epigenetic regulation (Fig. 8B). ...
Significant association of catechol-O-methyltransferase (COMT) haplotypes with nicotine dependence in male and female smokers of two ethnic populations. Neuropsychopharmacology 31: 675–684. Bierut LJ, Rice JP, Edenberg HJ, Goate A, Foroud T, Cloninger CR et al (2000). Family-based study of ...