The 2.2 Å structure of the rRNA methyltransferase ErmC′ and its complexes with cofactor and cofactor analogs: implications for the reaction mechanism. J. Mol. Biol. 289, 277–291 (1999). Article CAS PubMed Google Scholar Ferré-D’Amaré, A. R. & Doudna, J. A. Crystallization ...
The protein is an unusual case of an amino methyltransferase that has evolved to producing m5C. General significance Although, dispensable under optimal growth conditions, the presence of m5C may be important for recognition of parent strand and, thus, could contribute to the extraordinary DNA repair...
These data suggest that MAT2A activity is required for the m6A RNA methyltransferase-dependent control of protein synthesis. Moreover, supplementation of SAM led to the partial but significant rescue in the protein synthesis rate in response to MAT2A inhibition (Figures 6E and S6H). These data ...
Cytosine methyltransferaseProtein homeostasisBackground: Control of cellular processes by epigenetic modification of cytosine in DNA is widespread among living organisms, but, is hitherto unknown in the extremely radioresistant microbe D. radiodurans.Patil, Nayana A.Basu, BhaktiDeobagkar, Deepti D.Apte,...