S-phase cell cycle arrest, and apoptotic potential of Echium arabicum phenolic fraction in hepatocellular carcinoma HepG2 cellsNael AbutahaFahd A. AL-MekhlafiBader O. AlmutairiMuhammad A. WadaanJournal of King Saud University - Science
to achieve multiple round of the viral DNA replication. SV40 overrides cell cycle control in two distinct mechanisms. First, T-antigen impedes the progress of S phase in the cell cycle, thereby prolonging the S phase (ie, S phase arrest). How does T-antigen hold the progress of S phase?
Cite this article Radhakrishnan, S., Feliciano, C., Najmabadi, F.et al.Constitutive expression of E2F-1 leads to p21-dependent cell cycle arrest in S phase of the cell cycle.Oncogene23, 4173–4176 (2004). https://doi.org/10.1038/sj.onc.1207571 Download citation Received21 November 2003...
which transactivates the essential target genes for entering the S phase, while the transcriptional suppression of E2F target genes impedes the G1/S phase transition and causes cell cycle arrest30. We first performed qPCR analysis and confirmed that the transcription of several E2F target genes, in...
causing G1 cell cycle arrest and cell cycle delay. Luciferase assays established that Api5 directly regulates the expression of several G1/S genes under E2F1 control. Using protein/protein and protein/DNA immunoprecipitation studies, we demonstrate that Api5, even if not physically interacting...
Furthermore, CPT-11 induced cell cycle arrest in the temperature-sensitive S-phase, and increased lipid ROS levels contributed to the degradation of HSPs protein expression. This synergistic approach could effectively induce tumor cell death by the sensitized low-temperature PTT and the combination of...
Pignolo RJ, Martin BG, Horton JH, Kalbach AN, Cristofalo VJ (1998) The pathway of cell senescence: WI-38 cells arrest in late G1 and are unable to traverse the cell cycle from a true G0 state. Exp Gerontol 33:67–80 Qi Y, Gregory MA, Li Z, Brousal JP, West K, Hann SR (20...
An analysis of cell cycle arrest indicates the existence of (at least) two checkpoints for damaged DNA prior to S-phase; one at START (a G1 ... W Siede,AS Friedberg,I Dianova,... - 《Genetics》 被引量: 338发表: 1994年 Evidence that a free-running oscillator drives G1 events in...
J. CDK4/6 inhibition in cancer: beyond cell cycle arrest. Trends Cell Biol. 28, 911–925 (2018). Article CAS PubMed PubMed Central Google Scholar Schaer, D. A. et al. The CDK4/6 inhibitor abemaciclib induces a T cell inflamed tumor microenvironment and enhances the efficacy of PD-...
Protein kinases also function as checkpoint controls to ensure the proper completion and initiation of each phase in the cell cycle. These kinases arrest the cell cycle when a DNA mutation is detected. For example, p53 is a tumor suppressor which arrests cells with damaged DNA at the G1 check...