Glehnia littoralis Root Extract Induces G0/G1 Phase Cell Cycle Arrest in the MCF-7 Human Breast Cancer Cell Line. de la Cruz JF,Vergara EJ,Cho Y,et al. Asian Pacific Journal of Cancer Prevention . 2015de la Cruz JF,Vergara EJ,Cho Y,et al.Glehnia littoralis root extract induces G0/G1...
Proliferation by Decreasing the Cyclin D2 mRNA Expression and Cell Cycle Arrest at G1 PhasePradeep, P KLi, XiaolingPeegel, Helle
The normal cell cycle and G2/M arrest Thelife cycleof a dividing cell can be split into four stages: G1, S, G2 and mitosis, with cells that are no longer cycling being said to be quiescent or in G0. The two gap phases, G1 and G2, separate S phase, during which the DNA is...
Both compounds strongly inhibited proliferation of colon carcinoma cell lines by promoting G1 phase cell cycle arrest. Thiazolide-induced cell cycle arrest was independent of the p53/p21 axis, but was mediated by inhibition of protein translation via the mTOR/c-Myc/p27 pathway, likely caused by...
G1 phase arrest induced by IFN-λ1 To explain the mechanism of cell growth inhibition by IFN-λ1 concerning cell cycle change, we analyzed the effects of IFN-λ1 treatment on the cell cycle. As shown inTable I, the percentage of cells in the G1 phase increased, whereas the percentage ...
SIM+MET teatment led to an earlier, more pronounced, sustained, and significant G1-phase cell cycle arrest compared with SIM or MET treatment alone; this is sensible, as nutrient restriction generally leads to arrest at the G1-phase checkpoint....
In case conditions are unfavorable, the cell halts in a transient G1 arrest, activates reversible cell cycle–exit mechanisms to enter G0 (quiescence), or commits to a permanent cell-cycle arrest (senescence). During the S phase, DNA synthesis takes place to completely and accurately replicate ...
lncRNA GAS5 down-regulation reduced the YBX1 protein level, which decreased YBX1-transactivated p21 expression and abolished G1 phase cell cycle arrest in stomach cancer. These results delineate a novel mechanism of lncRNA GAS5 in suppressing stomach carcinogenesis and the lncRNA GAS5/YBX1/p21...
involvement of other factors in SSA-induced G1 phase arrest. 有效的剪接抑制剂 spliceostatin A (SSA) 抑制 G1 和 G2/M 期的细胞周期进程。我们之前报道过由CDKN1B编码的 p27 细胞周期蛋白依赖性激酶抑制剂及其 C 端截短形式,即从CDKN1B前体 mRNA翻译而来的 p27* 的上调是 SSA 治疗引起的 G1 期停滞...
Lin JT, Li HY, Chang NS, Lin CH, Chen YC and Lu PJ: WWOX suppresses prostate cancer cell progression through cyclin D1‑mediated cell cycle arrest in the G1 phase. Cell Cycle 14: 408‑416, 2015.WWOX suppresses prostate cancer cell progression through cyclin D1-...