Cellular senescence is a program that prevents malignant transformation in part by avoiding cell cycle progression.1 The senescent cell cycle arrest is controlled by the retinoblastoma protein (RB), which negatively regulates the activity of the E2F transcription factors, leading to repression of ...
Furthermore, abemaciclib has a slightly different pharmacological structure to palbociclib and ribociclib, and has antitumor effects related to the host’s immune system other than cell cycle arrest. With the rapid development of these new agents, alternative treatment strategies for recurrent breast ...
Corrigendum to “Physachenolide C induces complete regression of established murine melanoma tumors via apoptosis and cell cycle arrest” Translational Oncology, Volume 21, July 2022, Pages 101446 Anngela C. Adams, Anne M. Macy, Paul Kang, Karla F. Castro-Ochoa, E. M. Kithsiri Wijeratne, Ya...
A network of control pathways has been characterized that arrest growth or induce apoptosis in response to potentially tumorogenic events such as genotoxic... M Pearson,PG Pelicci - 《Oncogene》 被引量: 340发表: 2001年 Deconstructing PML-induced premature senescence In this study, we investigated...
Our results suggest that de novo lipogenesis is essential for cell cycle completion. This lipogenic checkpoint at G2/M may be therapeutically exploited for hyperproliferative diseases such as cancer. 展开 关键词: de novo lipogenesis phospholipid fatty acid cell cycle cell cycle arrest AMPK metabolome...
Aspidin BB, a phloroglucinol derivative, induces cell cycle arrest and apoptosis in human ovarian HO-8910 cells. Chemico-Biological Interactions 204, 88–97 (2013). Article Google Scholar Haixue, K. et al. Three drimane sesquiterpene glucoside from the aerial parts of Dryopteris fragrans (L.)...
cell proliferation and malignancy45,46. In the present report, the complete suppression of AC expression was found to cause a stronger reduction in proliferation and invasion capabilities compared to previous studies20. As described, the cell-permeant ceramide analog C6 causes cell cycle arrest in ...
October 8:XXXTencacion is arrested in Miami-Dade County, andchargedwith aggravated battery of a pregnant woman, domestic battery by strangulation, false imprisonment, and witness tampering. He pleads not guilty, but is detained by Broward County for violating his house arrest agreement. A trial ...
1.Sea cucumber extract Frondanol A5 was tested on two types of human pancreatic cancer cells in a 2010 study from the Feinberg School of Medicine in Chicago. “Frondanol-A5 causes cell cycle arrest and apoptosis in human pancreatic cancer cells,” concluded researchers, who further noted that ...
SD-36 inhibits the growth of a subset of acute myeloid leukemia and anaplastic large-cell lymphoma cell lines by inducing cell-cycle arrest and/or apoptosis. SD-36 achieves complete and long-lasting tumor regression in multiple xenograft mouse models at well-tolerated dose schedules. Degradation ...