细胞周期阻滞 DNA损伤发生后,由蛋白精氨酸N端甲基化转移酶5(PRMT5)介导的p53精氨酸甲基化能够导致细胞周期阻滞(cell-cycle arres… www.lifeomics.com|基于 1 个网页 3. 生长周期迟滞 (如前述);(2)直接抑制癌细胞活性,如:增生(proliferation)、生长周期迟滞(cell-cycle arrest)与诱导凋亡(apoptosis) ...
The cell cycle is necessarily complex, with sequentially activated cyclin-CDK complexes being regulated by multiple mechanisms at every stage. Checkpoints at G1/S and G2/M function as gatekeepers againstgenomic instability. Dysregulation of the molecules that enforce cell-cycle arrest at these checkpo...
Treatment of PC-3 cells with G-1 induced cell-cycle arrest at the Gphase and reduced the expression of G-checkpoint regulators (cyclin-A2, cyclin-B1, cdc25c, and cdc2) and phosphorylation of their common transcriptional regulator NF-YA in PC-3 cells. With extensive use of siRNA-knockdown ...
How cells coordinate cell cycling with cell survival and death remains incompletely understood. Here, we show that cell cycle arrest has a potent suppressive effect on ferroptosis, a form of regulated cell death induced by overwhelming lipid peroxidation
Review Cell Death and Differentiation (2018) 25, 114–132 Official journal of the Cell Death Differentiation Association www.nature.com/cdd Cell cycle arrest through indirect transcriptional repression by p53: I have a DREAM OPEN Kurt Engeland1 Activation of the p53 tumor suppressor can lead to ...
Abieslactone Induces Cell Cycle Arrest and Apoptosis in Human Hepatocellular Carcinomas through the Mitochondrial Pathway and the Generation of Reactive Ox... Lv, Z.-R. Shi et al., "Abieslactone induces cell cycle arrest and apoptosis in human hepatocellular carcinomas through the mitochondrial ...
These data demonstrate that Vif on its own was able to arrest cells at the G2 phase, but was less potent than cell cycle blockade by Vif and Vpr together. Figure 1 Vif causes prominent G2 arrest in the absence of Vpr. (A) Schematic of the NL4-3 HIV-1 molecular clones used. The ...
Moreover, flowcytometry and annexin-V analysis revealed that the ethanolic extract induced apoptosis and cell-cycle arrest in BHY cells at G1/S phase. In addition, colorimetric methods exhibited the highest amount of total phenolics and flavonoids in the aqueous and gum extracts (0.12 ± 0.037,...
Although Chk1 or Chk2 are known to trigger G2/M phase cell cycle arrest, these kinases are also known to mediate ATM-dependent G1 checkpoint due to activating p53 tumor suppressor protein by phosphorylation [7], [8]. Autophagy is a conservative process of protein degradation through ...
12). Therefore, cell-cycle arrest does not appear to have an additional effect beyond that of NICD on the expression of temporal-axis genes. We also examined the gene expression profiles of NICD/p18 co-expressing APs by using microarray (N=4). PCA on these cells with E11+E14 progenitors...