细胞周期阻滞 DNA损伤发生后,由蛋白精氨酸N端甲基化转移酶5(PRMT5)介导的p53精氨酸甲基化能够导致细胞周期阻滞(cell-cycle arres… www.lifeomics.com|基于 1 个网页 3. 生长周期迟滞 (如前述);(2)直接抑制癌细胞活性,如:增生(proliferation)、生长周期迟滞(cell-cycle arrest)与诱导凋亡(apoptosis) ...
Senescence is a cellular state characterized by an irreversible cell cycle arrest and functional and structural changes in response to diverse sources of stress. From: Trends in Cancer, 2024 About this pageSet alert Also in subject areas: Immunology and Microbiology Medicine and Dentistry Neuroscience...
Molecular stop signs: regulation of cell-cycle arrest by C/EBP transcription factors The CCAAT/enhancer-binding protein (C/EBP) family of transcription factors plays an important role in controlling cell proliferation and differentiation. C... Johnson,F P. - 《Journal of Cell Science》 被引量:...
How cells coordinate cell cycling with cell survival and death remains incompletely understood. Here, we show that cell cycle arrest has a potent suppressive effect on ferroptosis, a form of regulated cell death induced by overwhelming lipid peroxidation
Review Cell Death and Differentiation (2018) 25, 114–132 Official journal of the Cell Death Differentiation Association www.nature.com/cdd Cell cycle arrest through indirect transcriptional repression by p53: I have a DREAM OPEN Kurt Engeland1 Activation of the p53 tumor suppressor can lead to ...
Cell cycle arrest was induced in normal human fibroblasts (NHF1-hTERT) and normal human uroepithelial cells (HUCs), and TCC lines and checkpoint ... SC Doherty,McKeown Stephanie R.,McKelvey-Martin Valerie,... - 《Journal of the National Cancer Institute》 被引量: 136发表: 2003年 Cyclin...
Cellular quiescence is defined by arrest in a particular phase of the cell cycle, typically G1 or G2; however, the regulation of quiescence and proliferation can also be considered across wider scales in space and time. As such, quiescence is a defining feature of plant development and ...
The growth rate prior to starvation determines the number of chromosomes upon arrest. Nucleoids of these cells are decondensed; in the absence of the ability to synthesize ppGpp, nucleoids become highly condensed, similar to that seen after treatment with the translational inhibitor chloramphenicol....
12). Therefore, cell-cycle arrest does not appear to have an additional effect beyond that of NICD on the expression of temporal-axis genes. We also examined the gene expression profiles of NICD/p18 co-expressing APs by using microarray (N=4). PCA on these cells with E11+E14 progenitors...
Okamatsu-Ogura, Y., Fukano, K., Tsubota, A.et al.Cell-cycle arrest in mature adipocytes impairs BAT development but not WAT browning, and reduces adaptive thermogenesis in mice.Sci Rep7, 6648 (2017). https://doi.org/10.1038/s41598-017-07206-8 ...