cell cycle arrest细胞周期阻滞(Cell Cycle Arrest)是指细胞在细胞周期中不能顺利从一个阶段进入下一个阶段的现象。这种阻滞是细胞周期调控中的重要机制,对于维持细胞稳态、基因稳定性和防止疾病发生具有重要意义。 一、细胞周期阻滞的定义与意义 细胞周期阻滞通常由于细胞内外信号的缺乏或...
网络细胞周期受抑制;细胞周期阻滞;生长周期迟滞 网络释义 1. 细胞周期受抑制 ...们产生突变. 1.2. 细胞对DNA损伤的反应:细胞周期受抑制(cell-cycle arrest) 死亡 (apoptosis) 除DNA损伤物外,细胞必须 … wenku.baidu.com|基于 1 个网页 2. 细胞周期阻滞 ...
Cell cycle arrest Cell cycle is a highly conserved and precisely coordinated process, necessary for cell growth and division, which consist of four phases denominated as gap 1 (G1), synthesis (S), gap 2 (G2), and mitosis (M). Cell cycle is mainly regulated by complexes formed by cyclins...
Thecell cycle arrestand apoptosis of Hxo-rb44 cell were assayed with flow cytometry. 结论TSA可以有效诱导人Rb细胞株Hxo-rb44细胞周期阻滞和凋亡,其作用机制与抑制Survivin和c-Myc表达有关。 3. Objective To investigate the molecular mechanism of hypoxia inducingcell cycle arrestof human lung adenocarcinoma...
How cells coordinate cell cycling with cell survival and death remains incompletely understood. Here, we show that cell cycle arrest has a potent suppressive effect on ferroptosis, a form of regulated cell death induced by overwhelming lipid peroxidation
2023年11月16日,来自英国邓迪大学的Adrian T. Saurin团队在Molecular Cell上在线发表题为Oncogenic signals prime cancer cells for toxic cell growth during a G1 cell-cycle arrest的文章,证明CDK4/6抑制剂使细胞生长和细胞周期这两个过程解耦联,从而导致细胞过度生长、DNA损伤和细胞周期退出。致癌信号则加剧了这些...
cell-cycle arrest (This response can also be elicited by inhibiting or altering genes involved in telomere maintenance ) Type2 oxidative DNA damage at telomeric G-reach repeats telomere-associated foci (TAFs), can exist at telomeres (irrespective of telomere length or shelterin loss ) ...
aIm just a listener,hope you understand! 正在翻译,请等待...[translate] aI just send message to your handphone did you received 我寄发消息到您的handphone做了您接受了[translate] aGenerally, cell cycle arrest alone is not sufficient to 通常,单独细胞周期拘捕不是充足的[translate]...
Activation of the p53 tumor suppressor can lead to cell cycle arrest. The key mechanism of p53-mediated arrest is transcriptional downregulation of many cell cycle genes. In recent years it has become evident that p53-dependent repression is controlled b
Cell-cycle arrest and inhibition of Cdk4 activity by small peptides based on the carboxy-terminal domain of p21WAF1 BACKGROUND: A common event in the development of human neoplasia is the inactivation of a damage-inducible cell-cycle checkpoint pathway regulated by p53. ... KL Ball,S Lain,...