为解决t(8;21)急性髓系白血病(AML)中RUNX1-ETO融合蛋白的靶向治疗难题,研究人员通过配体虚拟筛选和生物物理验证,发现非电荷型小分子M23、M27和M10能特异性抑制NHR2域四聚化,其细胞活性较先导化合物7.44提升5-10倍,且具有优异膜渗透性。该研究为开发低毒性AML靶向药物提供了新候选分子。 急性髓系白血病(AML)是一...
急性髓系白血病属于一种血细胞异常增殖的疾病,病因是血细胞中位于21号带有RUNX1基因的染色体片段与8号染色体片段相互移接,使得8号染色体上形成了RUNX1—ETO融合基因,其表达产物会促进血细胞的恶性增殖。下列有关叙述不正确的是( )|1|+| A. 急性髓系白血病是遗传物质改变引发的遗传病,可遗传传给子代 B. 图示变异...
AML1-ETO leukemia is the most common cytogenetic subtype of acute myeloid leukemia, defined by the presence of t(8;21). Remarkable progress has been achieved in understanding the molecular pathogenesis of AML1-ETO leukemia. Proteomic surveies have shown that AML-ETO forms a stable complex with ...
你的孩子AML1-ETO基因(现在更新命名为:RUNX1-RUNX1T1基因),就这个基因本身而言,它的预后是相对好的,首选化疗,不得已才考虑做骨髓移植。我们科研究统计过这种基因阳性病例的五年生存率能到70-80%以上,但有些其他因素还会对预后产生影响,比如:孩子发病时的年龄,ETO基因下降的速度,c-KIT突变,有没有合并其他异常染...
产品小类:抗体 货号:6829-50 产品名称:Runx1/AML1-ETO polyclonal antibody Runx1/AML1-ETO polyclonal-北京博迈斯科技发展有限公司 英文名称:Runx1/AML1-ETO polyclonal antibody 品牌:biovision 规格:50 μl 价格:3675 说明: Runx1/AML1-ETO polyclonal antibody Host:Rabbit Antibody Type:Polyclonal Species Rea...
HY-151411CASNo.:88755-39-9分⼦式:C₁₈H₁₄O₇分⼦量:342.3作⽤靶点:Others作⽤通路:Others储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性RUNX1/ETOtetramerization-IN-1RUNX1/ETO四聚化的⼩分⼦抑制剂,具有抗⽩⾎病...
RUNX1T1-ETO polyclonal antibody, PAB31285, highly specific and rigorously validated in-house for ChIP, ChIP-Seq, ELISA (ELISA). Reacts with Human.RUNX1T1-ETO polyclonal antibody, PAB31285 is ready to ship.
However, it failed to interact with ETO-homologues, repress RUNX1 targets, and transform progenitors. Surprisingly, transforming capacity was fully restored by C-terminal fusion with ETO's NHR4 zinc-finger or the repressor domain 3 of N-CoR, while other repression domains failed. With an ...
化合物 RUNX1/ETO TETRAMERIZATION-IN-1 CAS号: 88755-39-9 英文名: Piperonal Related Compound 1 英文别名: TadalafilImpurity88;Piperonal Impurity 1;Piperonal Related Compound 1;RUNX1/ETO tetramerization-IN-1;1,3-Benzodioxole-5-butanoic acid, α-1,3-benzodioxol-5-yl-γ-oxo- 中文名: 化合物...
RUNX1-EVI1 directs a stem cell-like transcriptional network reliant on GATA2, whereas that of RUNX1-ETO-expressing cells is more mature and depends on RUNX1. However, both types of AML are dependent on the continuous expression of the fusion proteins. Our data provide a molecular explanation...