AML1-ETO (RUNX1-ETOAML1(RUNX1Acute myeloid leukemiaTranscription factor complexEpigeneticsSignal transductionDNA repairAML1-ETO leukemia is the most common cytogenetic subtype of acute myeloid leukemia, defined by the presence of t(8;21). Remarkable progress has been achieved in understanding the ...
急性髓系白血病属于一种血细胞异常增殖的疾病,病因是血细胞中位于21号带有RUNX1基因的染色体片段与8号染色体片段相互移接,使得8号染色体上形成了RUNX1—ETO融合基因,其表达产物会促进血细胞的恶性增殖。下列有关叙述不正确的是( )|1|+| A. 急性髓系白血病是遗传物质改变引发的遗传病,可遗传传给子代 B. 图示变异...
HY-151411CASNo.:88755-39-9分⼦式:C₁₈H₁₄O₇分⼦量:342.3作⽤靶点:Others作⽤通路:Others储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性RUNX1/ETOtetramerization-IN-1RUNX1/ETO四聚化的⼩分⼦抑制剂,具有抗⽩⾎病...
RUNX1T1-ETO polyclonal antibody, PAB31285, highly specific and rigorously validated in-house for ChIP, ChIP-Seq, ELISA (ELISA). Reacts with Human.RUNX1T1-ETO polyclonal antibody, PAB31285 is ready to ship.
你的孩子AML1-ETO基因(现在更新命名为:RUNX1-RUNX1T1基因),就这个基因本身而言,它的预后是相对好的,首选化疗,不得已才考虑做骨髓移植。我们科研究统计过这种基因阳性病例的五年生存率能到70-80%以上,但有些其他因素还会对预后产生影响,比如:孩子发病时的年龄,ETO基因下降的速度,c-KIT突变,有没有合并其他异常...
Over the decades, the RUNX1-ETO fusion gene created by t(8;21) has been introduced into various types of hematopoietic cells, largely at adult stage, in mice; however, all the previous attempts failed to generate tractable AML models. In stark contrast, we recently succeeded in inducing AML...
RUNX1-EVI1 directs a stem cell-like transcriptional network reliant on GATA2, whereas that of RUNX1-ETO-expressing cells is more mature and depends on RUNX1. However, both types of AML are dependent on the continuous expression of the fusion proteins. Our data provide a molecular explanation...
RUNX1–ETO-expressing cells, as well as a reduction in maturing granulocytes characteristic of t(8;21) leukaemia.6However, we detected no significant shift in the distributions of monocyte, granulocyte and erythrocyte populations in bulk cultures of MYCT1-expressing cells (Figure 3b), and the ...
Here, through characterization of transcriptional regulation by the RUNX1-ETO fusion protein, we have identified Ras-association domain family member 2 (RASSF2) as a critical gene that is aberrantly transcriptionally repressed in t(8;21)-associated AML. Re-expression of RASSF2 specifically inhibits ...
Runx1/AML1-ETO polyclonal antibody information, including chemical properties, structure, melting point, boiling point, density, formula, molecular weight, uses, prices, suppliers, SDS and more, available at Chemicalbook.