染色体检查发现异常染色体t(8;21),基因检测发现AML1-ETO(RUNX1-RUNX1T1)融合基因,诊断急性髓细胞白血病(AML)伴AML1-ETO融合基因,标准IA方案诱导治疗一疗程缓解,基因突变报告提示未见c-KIT突变,危险分组为低危组,继续氟达拉滨联合阿糖胞苷巩固治疗,一疗程后复查基因转为阴性;该患者继续巩固治疗4疗程结束治疗。
你的孩子AML1-ETO基因(现在更新命名为:RUNX1-RUNX1T1基因),就这个基因本身而言,它的预后是相对好的,首选化疗,不得已才考虑做骨髓移植。我们科研究统计过这种基因阳性病例的五年生存率能到70-80%以上,但有些其他因素还会对预后产生影响,比如:孩子发病时的年龄,ETO基因下降的速度,c-KIT突变,有没有合并其他异常染...
M2型白血病(AML-M2)常见的融合基因是AML1-ETO(RUNX1-RUNX1T1),由t(8;21)(q22;q22)易位形成,属于其标志性分子异常。其他选项分析如下: - **A. PML-RARα**:见于M3型白血病(APL),与t(15;17)相关。 - **C. PLZF-RARα**:M3型白血病的罕见变异型,与t(11;17)相关。 - **D. MLL(KMT2A)**:...
AML1-ETO是一种融合基因，它在急性髓细胞性白血病（AML）中发挥作用。这种融合基因是由一个被称为RUNX1或AML1的基因与另一个名为ETO或RUNX1T1的基因相互融合而产生的。AML1-ETO融合基因在急性髓细胞性白血病中的某些亚型中发现，特别是在M2亚型中。拷贝值1750000可能表示AML1-ETO融合基因的数量。在分...
In this issue o铆 Blood, Chou et al and Pulikkan et al reveal that the (8;21)(q22;q22) translocation product AML1-ETO (RUNX1-RUNX1T1) leads to enhanced JAK/STAT signaling downstream of myeloproliferative leukemia (MPL) virus, which in turn contributes to increased survival of tumor ...
Hybridization position of the probes on the chromosome. Self-Attestation Abnova self-attests to comply with the U.S. Framework for Nucleic Acid Synthesis Screening Applications Gene Info — RUNX1 Gene Info — RUNX1T1 Interactomes Pathways Diseases...
由于存在AML1-ETO阳性和髓外病变,该患者最终确诊为CML急变期。 结论伴t(9;22)和t(8;21)易位的CML患者临床及外周血均为典型CML表现,虽然外周血及骨髓涂片呈慢性期表现,但已出现髓外浸润及AML1-ETO融合基因阳性,推测可能是在Ph + CML的基础上发生二次打击。 关键词: 白血病,粒细胞,慢性;费城染色体;AML1-...
The translocation t(8;21)(q22;q22), which results in the fusion of the AML1 (RUNX1) and ETO (CBFA2T1) genes, is a recurrent aberration in acute myeloid leukemia (AML), preferentially correlated with FAB M2, and has the highest incidence in childhood AML. Because of the favorable ...
Treatment failure resulting from disease relapse in AML, including AML1-ETO (AE) (also known as RUNX1-RUNX1T1) (+) AML, remains a challenge [2]. Developing more sensitive MRD detection methods might improve current treatment strategies and prevent relapse. For AML with fusion genes, the ...
The AML1-ETO (RUNX1-RUNX1T1) fusion gene created by the chromosome translocation t(8;21) (q21;q22) is one of the essential contributors to leukemogenesis. Only a few studies in the literature have focused on fusion gene-derived circular RNAs (f-circRNAs). Here, we report several AML1-...