von Goessel H, Jacobs U, Semper S, Krumbholz M, Langer T, et al. (2009) Cluster analysis of genomic ETV6-RUNX1 (TEL-AML1) fusion sites in childhood acute lymphoblastic leukemia. Leuk Res 33: 1082-1088.von Goesse
探针设计 ETV6(TEL)基因标记为橘红色,总长度为600kb; AML1(RUNX1)标记为绿色,总长度为1100kb。 临床意义 急性淋巴细胞白血病ALL 参考文献 Morrow M, et al. (2007) Oncogene 26: 4404-14. Peter A, et al. (2009) Eur J Haematol 83: 420-32....
形态学提供基本诊断和方向;依据TEL-AML1(ETV6- RUNX1)和(或)t(12:21)(p13;q22),确定类型。 ALL伴超二倍体 1、临床要点 本型白血病/淋巴瘤细胞被定义为染色体常>50条,且<66条而通常无其他易位与染色体异常者。常见于儿童患者(婴儿与成人...
ALL 中常见的融合基因和染色体异位包括 BCR / ABL 融合基因,t( 9; 22 ) ( q34 ; q11) ; MLL /AF4 融 合基 因,t ( 4; 11 ) ( q21; q23 ) ; TEL /AML1 ( 又称为 ETV6 /RUNX1) 融合基因,t ( 12; 21 ) ( p13; q22 ) ; E2A /PBX1 融合基因,t( 1; 19) ( q23; p13) 等。
TEL-AML1阳性病例一般为前B-ALL, 该核型ALL约占总ALL的80%,预后较好。 在WHO 2016中命名为ETV6-RUNX1;ETV6→TEL,RUNX1→AML1。 文献学习 一、概念 急性淋巴细胞白血病,是指前体T或B淋巴细胞发生克隆性异常增殖的恶性疾病。白血病细胞起源于骨髓,确诊时骨髓中的...
Tiensiwakul P .Cloning and sequencing of ETV6/RUNX1(TEL/AML1) variant in acute lymphoblastic leukemia[J].Cancer Genet Cytogenet, 2004,149(1):85-88. DOI: 10.1016/j.cancergencyto.2003.07.003 . 返回引文位置Google Scholar 百度学术 万方数据 [4] Szczepański T , Harrison CJ , van Dongen JJ...
ETV6-RUNX1 (TEL-AML1) Deregulates the Erythropoietin Receptor (EPOR) and Promotes Cell Survivaldoi:10.1182/blood.V116.21.3641.3641... VT Moya,P Cardus,J Procter,... - 《Blood》 被引量: 0发表: 2010年 The Central Region of TEL (ETV6) Is Dispensable for the TEL/AML1 (ETV6/RUNX1) Leuke...
因此,CCLG-2008 方案的疗效及NCI 分层标 4 Forestier E ,Heyman M ,Andersen MK ,et al. Outcome of ETV6 / 准是否更适合TEL-AML1 + 儿 ALL , RUNX1-positive childhood acute lymphoblastic leukaemia in the NO- 童 仍需要延长观 PHO-ALL-1992 protocol :frequent late relapses but good overall sur...
ETV6/RUNX1-positive childhood acute lymphoblastic leukemia (ALL): The spectrum of clonal heterogeneity and its impact on prognosis Cancer Genetics, Volumes 224–225, 2018, pp. 1-11 M. Ampatzidou,…, S. PolychronopoulouAbout ScienceDirect Remote access Advertise Contact and support Terms and condi...
Conclusion Our findings suggest ETV6-RUNX1 is associated with space-time clustering of CL and are consistent with an infection interacting with that oncogene in early life leading to clinical leukemia.Christian KreisJudith E. LupatschFelix Niggli...